DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PSTST
Uniprot ID:
Q99715
Source protein:
Collagen alpha-1
Source gene:
COL12A1
Class:
DEG_SPOP_SBC_1
Location:
1855:1859
E3 ligase:
SPOP
DEGRON score:
0.7973
ASA_SCORE:
52.74
COIL:
0.6292
CONS_SCORE:
0.5102
DSS_SCORE:
0.4009
HELIX:
0.0296
FCONS_SCORE:
0.9505
RIG_SCORE:
0.7522
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N1849K
TCGA-10-0930
OV
TCGA
PSTST
DEG_SPOP_SBC_1
0.1667
p.N1849K
DO32113
OV
ICGC
PSTST
DEG_SPOP_SBC_1
0.1667
p.D1865Y
TCGA-55-8204
LUAD
TCGA
PSTST
DEG_SPOP_SBC_1
0.1667
p.D1865Y
DO45322
LUAD
ICGC
PSTST
DEG_SPOP_SBC_1
0.1667
p.R1863L
TCGA-66-2782
LUSC
TCGA
PSTST
DEG_SPOP_SBC_1
0.2222
p.R1863L
DO26680
LUSC
ICGC
PSTST
DEG_SPOP_SBC_1
0.2222
p.A1867T
TCGA-A6-5661
COAD
TCGA
PSTST
DEG_SPOP_SBC_1
0.1111
p.A1867T
DO8634
COAD
ICGC
PSTST
DEG_SPOP_SBC_1
0.1111
p.A1867T
ACH-000979
Prostate Cancer
CCLE
PSTST
DEG_SPOP_SBC_1
0.1111
p.L1860F
TCGA-CG-5733
STAD
TCGA
PSTST
DEG_SPOP_SBC_1
0.3056
p.L1860F
DO38551
STAD
ICGC
PSTST
DEG_SPOP_SBC_1
0.3056
p.W1864L
TCGA-D3-A2J8
SKCM
TCGA
PSTST
DEG_SPOP_SBC_1
0.1944
p.W1864L
DO37778
SKCM
ICGC
PSTST
DEG_SPOP_SBC_1
0.1944
p.R1851I
TCGA-EO-A3B0
UCEC
TCGA
PSTST
DEG_SPOP_SBC_1
0.2222
p.R1851I
DO219773
UCEC
ICGC
PSTST
DEG_SPOP_SBC_1
0.2222
p.P1855L
DO218882
SKCA
ICGC
PSTST
DEG_SPOP_SBC_1
0.7582
p.R1851K
SIDM00193
Colorectal Carcinoma
GDSC
PSTST
DEG_SPOP_SBC_1
0.2222
p.R1851K
ACH-000991
Colon/Colorectal Cancer
CCLE
PSTST
DEG_SPOP_SBC_1
0.2222
p.R1851K
SNU-81
large_intestine
COSMIC
PSTST
DEG_SPOP_SBC_1
0.2222
p.V1862A
SIDM01559
Melanoma
GDSC
PSTST
DEG_SPOP_SBC_1
0.25
p.V1862A
SIDM00159
Biliary Tract Carcinoma
GDSC
PSTST
DEG_SPOP_SBC_1
0.25
p.R1863C
ACH-002066
Sarcoma
CCLE
PSTST
DEG_SPOP_SBC_1
0.2222
p.P1852L
NCI-H520
lung
COSMIC
PSTST
DEG_SPOP_SBC_1
0.25
p.P1852L
SK-N-FI
autonomic_ganglia
COSMIC
PSTST
DEG_SPOP_SBC_1
0.25
Drug responses associated with COL12A1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75151
Lysine-specific demethylase PHF2
DEG_SPOP_SBC_1
966:970
PSTST
SPOP
0.9963
More...
P12270
Nucleoprotein TPR
DEG_SPOP_SBC_1
1809:1813
PSTST
SPOP
0.9674
More...
P18583
Protein SON
DEG_SPOP_SBC_1
320:324
PSTST
SPOP
0.9507
More...
P52756
RNA-binding protein 5
DEG_SPOP_SBC_1
432:436
PSTST
SPOP
0.9333
More...
Q00056
Homeobox protein Hox-A4
DEG_SPOP_SBC_1
310:314
PSTST
SPOP
0.9405
More...
Q12816
Trophinin
DEG_SPOP_SBC_1
1351:1355
PSTST
SPOP
0.9777
More...
Q14209
Transcription factor E2F2
DEG_SPOP_SBC_1
319:323
PSTST
SPOP
0.8702
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1129:1133
PSTST
SPOP
0.9421
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1170:1174
PSTST
SPOP
0.9246
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1211:1215
PSTST
SPOP
0.9576
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1252:1256
PSTST
SPOP
0.941
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1293:1297
PSTST
SPOP
0.8982
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1416:1420
PSTST
SPOP
0.9919
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1457:1461
PSTST
SPOP
0.7823
More...
Q14676
Mediator of DNA damage checkpoint protein 1
DEG_SPOP_SBC_1
1539:1543
PSTST
SPOP
0.9907
More...
Q5JQC9
A-kinase anchor protein 4
DEG_SPOP_SBC_1
131:135
PSTST
SPOP
0.6428
More...
Q7Z3K3
Pogo transposable element with ZNF domain
DEG_SPOP_SBC_1
253:257
PSTST
SPOP
0.9085
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
6882:6886
PSTST
SPOP
0.8449
More...
Q92546
RAB6A-GEF complex partner protein 2
DEG_SPOP_SBC_1
384:388
PSTST
SPOP
0.9331
More...
Q96EP1
E3 ubiquitin-protein ligase CHFR
DEG_SPOP_SBC_1
177:181
PSTST
SPOP
0.9967
More...
Q96G42
Kelch domain-containing protein 7B
DEG_SPOP_SBC_1
29:33
PSTST
SPOP
0.9278
More...
Q96PD2
Discoidin, CUB and LCCL domain-containing protein 2
DEG_SPOP_SBC_1
696:700
PSTST
SPOP
0.9984
More...
Q99102
Mucin-4
DEG_SPOP_SBC_1
506:510
PSTST
SPOP
0.6935
More...
Q99715
Collagen alpha-1
DEG_SPOP_SBC_1
1855:1859
PSTST
SPOP
0.7973
More...
Q99856
AT-rich interactive domain-containing protein 3A
DEG_SPOP_SBC_1
583:587
PSTST
SPOP
0.9473
More...
Q9BZF3
Oxysterol-binding protein-related protein 6
DEG_SPOP_SBC_1
200:204
PSTST
SPOP
0.9954
More...
Q9P2P6
StAR-related lipid transfer protein 9
DEG_SPOP_SBC_1
1859:1863
PSTST
SPOP
0.8119
More...
Q9P2R6
Arginine-glutamic acid dipeptide repeats protein
DEG_SPOP_SBC_1
1053:1057
PSTST
SPOP
0.8236
More...
Q9UBT2
SUMO-activating enzyme subunit 2
DEG_SPOP_SBC_1
576:580
PSTST
SPOP
0.891
More...
Q9UBU7
Protein DBF4 homolog A
DEG_SPOP_SBC_1
666:670
PSTST
SPOP
0.6306
More...
Q9ULU4
Protein kinase C-binding protein 1
DEG_SPOP_SBC_1
879:883
PSTST
SPOP
0.9313
More...
Q5T1B0
Axonemal dynein light chain domain-containing protein 1
DEG_SPOP_SBC_1
872:876
PSTST
SPOP
0.9934
More...
Q6PI47
BTB/POZ domain-containing protein KCTD18
DEG_SPOP_SBC_1
281:285
PSTST
SPOP
0.6017
More...
Q8N5C6
S1 RNA-binding domain-containing protein 1
DEG_SPOP_SBC_1
155:159
PSTST
SPOP
0.9948
More...
Q8TC56
Golgi associated RAB2 interactor protein 3
DEG_SPOP_SBC_1
250:254
PSTST
SPOP
0.9921
More...