DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SCF_FBW7_2

Location: 408:415

E3 ligase: FBXW7

DEGRON score: 0.9782

ASA_SCORE: 95.6375

COIL: 0.9591

CONS_SCORE: 0.758

DSS_SCORE: 0.6297

HELIX: 0.013

FCONS_SCORE: 0.955

RIG_SCORE: 0.5941

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T411S	TCGA-EK-A2R7	CESC	TCGA	PSATPVPE	DEG_SCF_FBW7_2	0.7116
p.T411S	DO49943	CESC	ICGC	PSATPVPE	DEG_SCF_FBW7_2	0.7116
p.S409C	DO1129	BRCA	ICGC	PSATPVPE	DEG_SCF_FBW7_2	0.643
p.P416H	DO47619	SKCM	ICGC	PSATPVPE	DEG_SCF_FBW7_2	0.3056
p.P416S	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	PSATPVPE	DEG_SCF_FBW7_2	0.3056
p.E417D	DO8264	COAD	ICGC	PSATPVPE	DEG_SCF_FBW7_2	0.2778
p.P417S	SIDM00845	Burkitt's Lymphoma	GDSC	PSATPVPE	DEG_SCF_FBW7_2	0.2778
p.M405I	DO228976	LICA	ICGC	PSATPVPE	DEG_SCF_FBW7_2	0.25

Showing 1 to 8 of 8 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18583	Protein SON	DEG_SCF_FBW7_2	408:415	PSATPVPE	FBXW7	0.9782	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons