DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SCF_FBW7_2

Location: 397:404

E3 ligase: FBXW7

DEGRON score: 0.9923

ASA_SCORE: 99.5

COIL: 0.9306

CONS_SCORE: 0.8351

DSS_SCORE: 0.6504

HELIX: 0.0184

FCONS_SCORE: 1.0784

RIG_SCORE: 0.6541

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S390C	TCGA-C8-A26Y	BRCA	TCGA	PPVTPVLE	DEG_SCF_FBW7_2	0.1389
p.S390C	DO1273	BRCA	ICGC	PPVTPVLE	DEG_SCF_FBW7_2	0.1389
p.S390F	TCGA-EE-A29D	SKCM	TCGA	PPVTPVLE	DEG_SCF_FBW7_2	0.1389
p.S390F	DO38123	SKCM	ICGC	PPVTPVLE	DEG_SCF_FBW7_2	0.1389
p.M405I	DO228976	LICA	ICGC	PPVTPVLE	DEG_SCF_FBW7_2	0.3056
p.L394F	SIDM00578	Neuroblastoma	GDSC	PPVTPVLE	DEG_SCF_FBW7_2	0.25
p.L394F	ACH-000804	Neuroblastoma	CCLE	PPVTPVLE	DEG_SCF_FBW7_2	0.25
p.L394F	NB1	autonomic_ganglia	COSMIC	PPVTPVLE	DEG_SCF_FBW7_2	0.25
p.P397S	ACH-002161	Gastric Cancer	CCLE	PPVTPVLE	DEG_SCF_FBW7_2	0.6752
p.P397S	MKN28	stomach	COSMIC	PPVTPVLE	DEG_SCF_FBW7_2	0.6752
p.M392R	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	PPVTPVLE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18583	Protein SON	DEG_SCF_FBW7_2	397:404	PPVTPVLE	FBXW7	0.9923	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons