DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_ODPH_VHL_1

Location: 1496:1507

E3 ligase: VHL

DEGRON score: 0.9455

ASA_SCORE: 83.7

COIL: 0.6938

CONS_SCORE: 0.7694

DSS_SCORE: 0.5562

HELIX: 0.1444

FCONS_SCORE: 1.0062

RIG_SCORE: 0.7212

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1515S	TCGA-A6-3809	COAD	TCGA	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.1111
p.A1515S	DO8722	COAD	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.1111
p.A1515D	TCGA-B5-A1MX	UCEC	TCGA	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.1111
p.A1515D	DO41999	UCEC	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.1111
p.H1508Y	TCGA-G4-6586	COAD	TCGA	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.3056
p.H1508Y	DO9698	COAD	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.3056
p.A1515V	TCGA-GN-A26C	SKCM	TCGA	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.1111
p.A1515V	DO37782	SKCM	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.1111
p.M1502I	DO229010	COCA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.6507
p.M1502I	DO229013	COCA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.6507
p.M1502I	DO229003	COCA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.6507
p.M1502I	DO229505	LAML	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.6507
p.M1502I	DO230527	LUSC	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.6507
p.I1487V	DO233073	GACA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.0833
p.N1495S	DO233203	GACA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.3056
p.Q1503L	DO233854	GACA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.6654
p.D1493V	DO231658	LINC	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.25
p.N1488S	SIDM00969	Ovarian Carcinoma	GDSC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.1111
p.N1488S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18583	Protein SON	DEG_ODPH_VHL_1	1496:1507	LAPEIGMQEIAL	VHL	0.9455	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons