DegronMD - Q8TEP8(CEP192)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1353S	TCGA-19-1389	GBM	TCGA	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.G1353S	DO12382	GBM	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.T416A	TCGA-A6-5665	COAD	TCGA	KTVLHMD	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.0833
p.T416A	DO9756	COAD	ICGC	KTVLHMD	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.0833
p.S906R	TCGA-AA-3984	COAD	TCGA	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.7427
p.S906R	DO9002	COAD	ICGC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.7427
p.C396S	TCGA-AP-A1DP	UCEC	TCGA	KTVLHMD	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.1944
p.C396S	DO42336	UCEC	ICGC	KTVLHMD	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.1944
p.T682M	TCGA-AP-A1DR	UCEC	TCGA	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.0556
p.T682M	DO43747	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.0556
p.G435E	TCGA-BS-A0UV	UCEC	TCGA	DSGINFT	DEG_SCF_TRCP1_1	433:439	Mutation altering degron motif	0.7199
p.G435E	DO42793	UCEC	ICGC	DSGINFT	DEG_SCF_TRCP1_1	433:439	Mutation altering degron motif	0.7199
p.G1353D	TCGA-CJ-4899	KIRC	TCGA	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.G1353D	DO16233	KIRC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.E1359G	TCGA-DI-A1BU	UCEC	TCGA	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.25
p.E1359G	DO42023	UCEC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.25
p.S1363L	TCGA-EE-A2GM	SKCM	TCGA	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.7667
p.S1363L	DO37555	SKCM	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.7667
p.N677S	TCGA-EL-A3GV	THCA	TCGA	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1944
p.N677S	DO39628	THCA	ICGC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1944
p.S908L	TCGA-FR-A726	SKCM	TCGA	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation rewiring degron network	0.2778
p.S908L	DO48665	SKCM	ICGC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation rewiring degron network	0.2778
p.S899L	TCGA-JW-A5VJ	CESC	TCGA	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation rewiring degron network	0.3056
p.S899L	DO49974	CESC	ICGC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation rewiring degron network	0.3056
p.Q664K	TCGA-KQ-A41N	BLCA	TCGA	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.2222
p.Q664K	DO223588	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.2222
p.E1376K	TCGA-P3-A5Q5	HNSC	TCGA	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.E1376K	DO44450	HNSC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.V1352I	TCGA-UY-A9PB	BLCA	TCGA	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0556
p.V1352I	DO219041	BLCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0556
p.G1370W	TCGA-XF-A8HE	BLCA	TCGA	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.25
p.G1370W	DO49797	BLCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.25
p.E1376Q	TCGA-XF-A9T5	BLCA	TCGA	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.E1376Q	DO51925	BLCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.D905H	DO224905	BRCA	ICGC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.6577
p.T671I	DO223390	CLLE	ICGC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation altering degron motif	0.7078
p.T680M	DO222864	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1111
p.V1365M	DO229013	COCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO229016	COCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO229003	COCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO229005	COCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO229346	LAML	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO229480	LAML	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO230659	LAML	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO231140	LAML	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO230990	LUSC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO52365	LUSC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.V1365M	DO231169	LUSC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.6097
p.R1373Q	DO50315	ESAD	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.1667
p.A441V	DO223076	ESCA	ICGC	DSGINFT	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.2778
p.M406K	DO228694	LICA	ICGC	KTVLHMD	LIG_APCC_ABBAyCdc20_2	401:407	Mutation altering degron motif	0.6951
p.G1364R	DO228947	LICA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation altering degron motif	0.7568
p.A667S	DO228976	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.3056
p.A667S	DO229019	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.3056
p.W1361L	DO229036	LICA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.3056
p.S434I	DO229008	LICA	ICGC	DSGINFT	DEG_SCF_TRCP1_1	433:439	Mutation altering degron motif	0.7341
p.T902S	DO220847	MELA	ICGC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.7116
p.S427F	DO222516	MELA	ICGC	DSGINFT	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.1667
p.E1376A	SIDM00303	Ovarian Carcinoma	GDSC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.E1376A	ACH-000584	Ovarian Cancer	CCLE	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.E1376A	JHOS-4	ovary	COSMIC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.0833
p.I661V	SIDM00450	Acute Myeloid Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1389
p.I661V	SIDM00617	Hepatocellular Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1389
p.I661V	SIDM01172	Acute Myeloid Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1389
p.I661V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1389
p.I661V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1389
p.I661V	SIDM00279	Gastric Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1389
p.I661V	SIDM01435	Hepatocellular Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.1389
p.P903L	SIDM00007	Other Solid Cancers	GDSC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.7582
p.P903L	ACH-001550	Skin Cancer	CCLE	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.7582
p.P903L	MCC13	skin	COSMIC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.7582
p.L905H	RCC-FG2	kidney	COSMIC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.7313
p.A914T	SNU-1040	large intestine	COSMIC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation rewiring degron network	0.1111
p.E901A	JHOS-4	ovary	COSMIC	ISTPSDS	DEG_SCF_FBW7_1	900:906	Mutation altering degron motif	0.7701
p.P428L	MCC13	skin	COSMIC	DSGINFT	DEG_SCF_TRCP1_1	433:439	Mutation rewiring degron network	0.1944
p.H1358Y	LU-165	lung	COSMIC	DSGVTS	DEG_SCF_TRCP1_1	1362:1367	Mutation rewiring degron network	0.2222
p.S682L	PANC-08-13	pancreas	COSMIC	VESTS	DEG_SPOP_SBC_1	668:672	Mutation rewiring degron network	0.0556
p.A400T	SW48	large intestine	COSMIC	KTVLHMD	LIG_APCC_ABBAyCdc20_2	401:407	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CEP192

UniProt ID: Q8TEP8

Entrez ID: 55125

Protein name: Centrosomal protein of 192 kDa (Cep192) (Cep192/SPD-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CEP192 in