DegronMD

Uniprot ID: Q8TEP8

Source protein: Centrosomal protein of 192 kDa

Source gene: CEP192

Class: DEG_SCF_TRCP1_1

Location: 1362:1367

E3 ligase: BTRC

DEGRON score: 0.7618

ASA_SCORE: 67.4667

COIL: 0.8457

CONS_SCORE: 0.4323

DSS_SCORE: 0.3605

HELIX: 0.0842

FCONS_SCORE: 1.0428

RIG_SCORE: 0.756

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1353S	TCGA-19-1389	GBM	TCGA	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.G1353S	DO12382	GBM	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.G1353D	TCGA-CJ-4899	KIRC	TCGA	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.G1353D	DO16233	KIRC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.E1359G	TCGA-DI-A1BU	UCEC	TCGA	DSGVTS	DEG_SCF_TRCP1_1	0.25
p.E1359G	DO42023	UCEC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.25
p.S1363L	TCGA-EE-A2GM	SKCM	TCGA	DSGVTS	DEG_SCF_TRCP1_1	0.7667
p.S1363L	DO37555	SKCM	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.7667
p.E1376K	TCGA-P3-A5Q5	HNSC	TCGA	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.E1376K	DO44450	HNSC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.V1352I	TCGA-UY-A9PB	BLCA	TCGA	DSGVTS	DEG_SCF_TRCP1_1	0.0556
p.V1352I	DO219041	BLCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.0556
p.G1370W	TCGA-XF-A8HE	BLCA	TCGA	DSGVTS	DEG_SCF_TRCP1_1	0.25
p.G1370W	DO49797	BLCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.25
p.E1376Q	TCGA-XF-A9T5	BLCA	TCGA	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.E1376Q	DO51925	BLCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.V1365M	DO229013	COCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO229016	COCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO229003	COCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO229005	COCA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO229346	LAML	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO229480	LAML	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO230659	LAML	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO231140	LAML	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO230990	LUSC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO52365	LUSC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.V1365M	DO231169	LUSC	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.6097
p.R1373Q	DO50315	ESAD	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.1667
p.G1364R	DO228947	LICA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.7568
p.W1361L	DO229036	LICA	ICGC	DSGVTS	DEG_SCF_TRCP1_1	0.3056
p.E1376A	SIDM00303	Ovarian Carcinoma	GDSC	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.E1376A	ACH-000584	Ovarian Cancer	CCLE	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.E1376A	JHOS-4	ovary	COSMIC	DSGVTS	DEG_SCF_TRCP1_1	0.0833
p.H1358Y	LU-165	lung	COSMIC	DSGVTS	DEG_SCF_TRCP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVTS

Degron related mutations and impact score

Drug responses associated with CEP192 mutations

All proteins holding degron of DSGVTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SCF_TRCP1_1	1362:1367	DSGVTS	BTRC	0.7618	More...