DegronMD

Uniprot ID: Q8TEP8

Source protein: Centrosomal protein of 192 kDa

Source gene: CEP192

Class: LIG_APCC_ABBAyCdc20_2

Location: 401:407

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8797

ASA_SCORE: 81.0286

COIL: 0.6601

CONS_SCORE: 0.329

DSS_SCORE: 0.4319

HELIX: 0.1011

FCONS_SCORE: 0.8921

RIG_SCORE: 0.7875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T416A	TCGA-A6-5665	COAD	TCGA	KTVLHMD	LIG_APCC_ABBAyCdc20_2	0.0833
p.T416A	DO9756	COAD	ICGC	KTVLHMD	LIG_APCC_ABBAyCdc20_2	0.0833
p.C396S	TCGA-AP-A1DP	UCEC	TCGA	KTVLHMD	LIG_APCC_ABBAyCdc20_2	0.1944
p.C396S	DO42336	UCEC	ICGC	KTVLHMD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M406K	DO228694	LICA	ICGC	KTVLHMD	LIG_APCC_ABBAyCdc20_2	0.6951
p.A400T	SW48	large_intestine	COSMIC	KTVLHMD	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEP8	Centrosomal protein of 192 kDa	LIG_APCC_ABBAyCdc20_2	401:407	KTVLHMD	APC,CDC20,FZR1	0.8797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons