DegronMD

Uniprot ID: Q8TEP8

Source protein: Centrosomal protein of 192 kDa

Source gene: CEP192

Class: DEG_SCF_TRCP1_1

Location: 433:439

E3 ligase: BTRC

DEGRON score: 0.8937

ASA_SCORE: 64.3714

COIL: 0.7496

CONS_SCORE: 0.3575

DSS_SCORE: 0.3191

HELIX: 0.1707

FCONS_SCORE: 1.1341

RIG_SCORE: 0.7477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G435E	TCGA-BS-A0UV	UCEC	TCGA	DSGINFT	DEG_SCF_TRCP1_1	0.7199
p.G435E	DO42793	UCEC	ICGC	DSGINFT	DEG_SCF_TRCP1_1	0.7199
p.A441V	DO223076	ESCA	ICGC	DSGINFT	DEG_SCF_TRCP1_1	0.2778
p.S434I	DO229008	LICA	ICGC	DSGINFT	DEG_SCF_TRCP1_1	0.7341
p.S427F	DO222516	MELA	ICGC	DSGINFT	DEG_SCF_TRCP1_1	0.1667
p.P428L	MCC13	skin	COSMIC	DSGINFT	DEG_SCF_TRCP1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SCF_TRCP1_1	433:439	DSGINFT	BTRC	0.8937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons