DegronMD

Uniprot ID: Q8TEP8

Source protein: Centrosomal protein of 192 kDa

Source gene: CEP192

Class: DEG_SCF_FBW7_1

Location: 900:906

E3 ligase: FBXW7

DEGRON score: 0.857

ASA_SCORE: 83.2143

COIL: 0.8736

CONS_SCORE: 0.3993

DSS_SCORE: 0.5314

HELIX: 0.0554

FCONS_SCORE: 0.7459

RIG_SCORE: 0.6673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S906R	TCGA-AA-3984	COAD	TCGA	ISTPSDS	DEG_SCF_FBW7_1	0.7427
p.S906R	DO9002	COAD	ICGC	ISTPSDS	DEG_SCF_FBW7_1	0.7427
p.S908L	TCGA-FR-A726	SKCM	TCGA	ISTPSDS	DEG_SCF_FBW7_1	0.2778
p.S908L	DO48665	SKCM	ICGC	ISTPSDS	DEG_SCF_FBW7_1	0.2778
p.S899L	TCGA-JW-A5VJ	CESC	TCGA	ISTPSDS	DEG_SCF_FBW7_1	0.3056
p.S899L	DO49974	CESC	ICGC	ISTPSDS	DEG_SCF_FBW7_1	0.3056
p.D905H	DO224905	BRCA	ICGC	ISTPSDS	DEG_SCF_FBW7_1	0.6577
p.T902S	DO220847	MELA	ICGC	ISTPSDS	DEG_SCF_FBW7_1	0.7116
p.P903L	SIDM00007	Other Solid Cancers	GDSC	ISTPSDS	DEG_SCF_FBW7_1	0.7582
p.P903L	ACH-001550	Skin Cancer	CCLE	ISTPSDS	DEG_SCF_FBW7_1	0.7582
p.P903L	MCC13	skin	COSMIC	ISTPSDS	DEG_SCF_FBW7_1	0.7582
p.L905H	RCC-FG2	kidney	COSMIC	ISTPSDS	DEG_SCF_FBW7_1	0.7313
p.A914T	SNU-1040	large_intestine	COSMIC	ISTPSDS	DEG_SCF_FBW7_1	0.1111
p.E901A	JHOS-4	ovary	COSMIC	ISTPSDS	DEG_SCF_FBW7_1	0.7701

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SCF_FBW7_1	900:906	ISTPSDS	FBXW7	0.857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons