DegronMD - Q9Y4G2(PLEKHM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W674L	TCGA-55-A490	LUAD	TCGA	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.5904
p.E329D	TCGA-58-A46N	LUSC	TCGA	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.25
p.F672L	TCGA-64-1676	LUAD	TCGA	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation rewiring degron network	0.3056
p.D683H	TCGA-66-2785	LUSC	TCGA	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation rewiring degron network	0.3056
p.D385Y	TCGA-80-5608	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1944
p.S688Y	TCGA-A5-A0G1	UCEC	TCGA	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation rewiring degron network	0.1667
p.Q396H	TCGA-AA-3510	COAD	TCGA	VESTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.2778
p.S675L	TCGA-AZ-6601	COAD	TCGA	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.6556
p.S675L	SIDM00457	Plasma Cell Myeloma	GDSC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.6556
p.S675L	SIDM00986	Head and Neck Carcinoma	GDSC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.6556
p.S675L	SIDM01470	Acute Myeloid Leukemia	GDSC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.6556
p.S675L	OPM-2	haematopoietic and lymphoid tissue	COSMIC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.6556
p.S675L	BHY	upper aerodigestive tract	COSMIC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.6556
p.E391Q	TCGA-C8-A1HM	BRCA	TCGA	VESTS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.5633
p.S338L	TCGA-DK-A1AC	BLCA	TCGA	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation altering degron motif	0.7667
p.I685T	TCGA-DU-6392	LGG	TCGA	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation rewiring degron network	0.25
p.G325R	TCGA-HT-7607	LGG	TCGA	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1389
p.Q388R	TCGA-LG-A6GG	LIHC	TCGA	VESTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.2778
p.P682S	TCGA-WS-AB45	COAD	TCGA	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.6752
p.R397G	DO234424	ESAD	ICGC	VESTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.25
p.L682Q	DO52087	HNSC	ICGC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.7765
p.R684C	DO229446	SKCA	ICGC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation rewiring degron network	0.2778
p.R684C	DO42665	UCEC	ICGC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation rewiring degron network	0.2778
p.G380W	DO37405	SKCM	ICGC	VESTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.0556
p.A404V	DO42312	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.0556
p.A673T	DO41235	UCEC	ICGC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.7139
p.T348I	SIDM01198	Burkitt's Lymphoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.0556
p.T348I	ACH-000567	Lymphoma	CCLE	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.0556
p.T348I	ST486	haematopoietic and lymphoid tissue	COSMIC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.0556
p.G325A	SIDM00874	Breast Carcinoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1389
p.G325A	ACH-000223	Breast Cancer	CCLE	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1389
p.G325A	HCC1937	breast	COSMIC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.1389
p.T323A	SIDM01045	Endometrial Carcinoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.0833
p.T323A	ACH-000978	Endometrial/Uterine Cancer	CCLE	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.0833
p.T323A	EN	endometrium	COSMIC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.0833
p.L341F	SIDM00469	Pancreatic Carcinoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.25
p.L341F	ACH-000320	Pancreatic Cancer	CCLE	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.25
p.L341F	PSN1	pancreas	COSMIC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation rewiring degron network	0.25
p.D673Y	SIDM01229	Neuroblastoma	GDSC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.7325
p.D673Y	ACH-002217	Neuroblastoma	CCLE	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.7325
p.D673Y	BE2-M17	autonomic ganglia	COSMIC	DWSSAQVPEP	DEG_COP1_1	673:682	Mutation altering degron motif	0.7325
p.Q336H	SIDM01664	Prostate Carcinoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation altering degron motif	0.647
p.Q336H	ACH-000952	Prostate Cancer	CCLE	IPTPQAS	DEG_SCF_FBW7_1	332:338	Mutation altering degron motif	0.647

Kaplan plot for PLEKHM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHM1

UniProt ID: Q9Y4G2

Entrez ID: 9842

Protein name: Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHM1 in