DegronMD

Uniprot ID: Q9Y4G2

Source protein: Pleckstrin homology domain-containing family M member 1

Source gene: PLEKHM1

Class: DEG_SCF_FBW7_1

Location: 332:338

E3 ligase: FBXW7

DEGRON score: 0.9782

ASA_SCORE: 75.7

COIL: 0.8729

CONS_SCORE: 0.2329

DSS_SCORE: 0.5553

HELIX: 0.0874

FCONS_SCORE: 0.904

RIG_SCORE: 0.7101

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E329D	TCGA-58-A46N	LUSC	TCGA	IPTPQAS	DEG_SCF_FBW7_1	0.25
p.S338L	TCGA-DK-A1AC	BLCA	TCGA	IPTPQAS	DEG_SCF_FBW7_1	0.7667
p.G325R	TCGA-HT-7607	LGG	TCGA	IPTPQAS	DEG_SCF_FBW7_1	0.1389
p.T348I	SIDM01198	Burkitt's Lymphoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	0.0556
p.T348I	ACH-000567	Lymphoma	CCLE	IPTPQAS	DEG_SCF_FBW7_1	0.0556
p.T348I	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	IPTPQAS	DEG_SCF_FBW7_1	0.0556
p.G325A	SIDM00874	Breast Carcinoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	0.1389
p.G325A	ACH-000223	Breast Cancer	CCLE	IPTPQAS	DEG_SCF_FBW7_1	0.1389
p.G325A	HCC1937	breast	COSMIC	IPTPQAS	DEG_SCF_FBW7_1	0.1389
p.T323A	SIDM01045	Endometrial Carcinoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	0.0833
p.T323A	ACH-000978	Endometrial/Uterine Cancer	CCLE	IPTPQAS	DEG_SCF_FBW7_1	0.0833
p.T323A	EN	endometrium	COSMIC	IPTPQAS	DEG_SCF_FBW7_1	0.0833
p.L341F	SIDM00469	Pancreatic Carcinoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	0.25
p.L341F	ACH-000320	Pancreatic Cancer	CCLE	IPTPQAS	DEG_SCF_FBW7_1	0.25
p.L341F	PSN1	pancreas	COSMIC	IPTPQAS	DEG_SCF_FBW7_1	0.25
p.Q336H	SIDM01664	Prostate Carcinoma	GDSC	IPTPQAS	DEG_SCF_FBW7_1	0.647
p.Q336H	ACH-000952	Prostate Cancer	CCLE	IPTPQAS	DEG_SCF_FBW7_1	0.647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SCF_FBW7_1	332:338	IPTPQAS	FBXW7	0.9782	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons