DegronMD

Uniprot ID: Q9Y4G2

Source protein: Pleckstrin homology domain-containing family M member 1

Source gene: PLEKHM1

Class: DEG_COP1_1

Location: 673:682

E3 ligase: COP1

DEGRON score: 0.9711

ASA_SCORE: 79.25

COIL: 0.8106

CONS_SCORE: 0.2384

DSS_SCORE: 0.3917

HELIX: 0.1494

FCONS_SCORE: 0.8983

RIG_SCORE: 0.7619

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L682Q	DO52087	HNSC	ICGC	DWSSAQVPEP	DEG_COP1_1	0.7765
p.D673Y	SIDM01229	Neuroblastoma	GDSC	DWSSAQVPEP	DEG_COP1_1	0.7325
p.D673Y	ACH-002217	Neuroblastoma	CCLE	DWSSAQVPEP	DEG_COP1_1	0.7325
p.D673Y	BE2-M17	autonomic_ganglia	COSMIC	DWSSAQVPEP	DEG_COP1_1	0.7325
p.A673T	DO41235	UCEC	ICGC	DWSSAQVPEP	DEG_COP1_1	0.7139
p.P682S	TCGA-WS-AB45	COAD	TCGA	DWSSAQVPEP	DEG_COP1_1	0.6752
p.S675L	TCGA-AZ-6601	COAD	TCGA	DWSSAQVPEP	DEG_COP1_1	0.6556
p.S675L	SIDM00457	Plasma Cell Myeloma	GDSC	DWSSAQVPEP	DEG_COP1_1	0.6556
p.S675L	SIDM00986	Head and Neck Carcinoma	GDSC	DWSSAQVPEP	DEG_COP1_1	0.6556
p.S675L	SIDM01470	Acute Myeloid Leukemia	GDSC	DWSSAQVPEP	DEG_COP1_1	0.6556
p.S675L	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	DWSSAQVPEP	DEG_COP1_1	0.6556
p.S675L	BHY	upper_aerodigestive_tract	COSMIC	DWSSAQVPEP	DEG_COP1_1	0.6556
p.W674L	TCGA-55-A490	LUAD	TCGA	DWSSAQVPEP	DEG_COP1_1	0.5904
p.F672L	TCGA-64-1676	LUAD	TCGA	DWSSAQVPEP	DEG_COP1_1	0.3056
p.D683H	TCGA-66-2785	LUSC	TCGA	DWSSAQVPEP	DEG_COP1_1	0.3056
p.R684C	DO229446	SKCA	ICGC	DWSSAQVPEP	DEG_COP1_1	0.2778
p.R684C	DO42665	UCEC	ICGC	DWSSAQVPEP	DEG_COP1_1	0.2778
p.I685T	TCGA-DU-6392	LGG	TCGA	DWSSAQVPEP	DEG_COP1_1	0.25
p.S688Y	TCGA-A5-A0G1	UCEC	TCGA	DWSSAQVPEP	DEG_COP1_1	0.1667

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_COP1_1	673:682	DWSSAQVPEP	COP1	0.9711	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons