DegronMD

Uniprot ID: Q9Y4G2

Source protein: Pleckstrin homology domain-containing family M member 1

Source gene: PLEKHM1

Class: DEG_SPOP_SBC_1

Location: 390:394

E3 ligase: SPOP

DEGRON score: 0.9903

ASA_SCORE: 78.16

COIL: 0.7642

CONS_SCORE: 0.2746

DSS_SCORE: 0.8146

HELIX: 0.069

FCONS_SCORE: 1.0445

RIG_SCORE: 0.5908

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E391Q	TCGA-C8-A1HM	BRCA	TCGA	VESTS	DEG_SPOP_SBC_1	0.5633
p.Q396H	TCGA-AA-3510	COAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.2778
p.Q388R	TCGA-LG-A6GG	LIHC	TCGA	VESTS	DEG_SPOP_SBC_1	0.2778
p.R397G	DO234424	ESAD	ICGC	VESTS	DEG_SPOP_SBC_1	0.25
p.D385Y	TCGA-80-5608	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	0.1944
p.G380W	DO37405	SKCM	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556
p.A404V	DO42312	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 7 of 7 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQW6	Anillin	DEG_SPOP_SBC_1	88:92	VESTS	SPOP	0.9904	More...
Q8TEP8	Centrosomal protein of 192 kDa	DEG_SPOP_SBC_1	668:672	VESTS	SPOP	0.5574	More...
Q04656	Copper-transporting ATPase 1	DEG_SPOP_SBC_1	351:355	VESTS	SPOP	0.6792	More...
P41229	Lysine-specific demethylase 5C	DEG_SPOP_SBC_1	283:287	VESTS	SPOP	0.9432	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	245:249	VESTS	SPOP	0.9923	More...
Q14693	Phosphatidate phosphatase LPIN1	DEG_SPOP_SBC_1	451:455	VESTS	SPOP	0.9287	More...
Q9Y4G2	Pleckstrin homology domain-containing family M member 1	DEG_SPOP_SBC_1	390:394	VESTS	SPOP	0.9903	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	335:339	VESTS	SPOP	0.6175	More...
Q6UX34	Protein SNORC	DEG_SPOP_SBC_1	49:53	VESTS	SPOP	0.8482	More...
P18583	Protein SON	DEG_SPOP_SBC_1	279:283	VESTS	SPOP	0.9537	More...
Q96H15	T-cell immunoglobulin and mucin domain-containing protein 4	DEG_SPOP_SBC_1	240:244	VESTS	SPOP	0.993	More...
P13611	Versican core protein	DEG_SPOP_SBC_1	2290:2294	VESTS	SPOP	0.6598	More...

Showing 1 to 12 of 12 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons