DegronMD

Uniprot ID: Q9BY11

Source protein: Protein kinase C and casein kinase substrate in neurons protein 1

Source gene: PACSIN1

Class: DEG_SPOP_SBC_1

Location: 310:314

E3 ligase: SPOP

DEGRON score: 0.946

ASA_SCORE: 66.64

COIL: 0.7036

CONS_SCORE: 0.3614

DSS_SCORE: 0.6724

HELIX: 0.1064

FCONS_SCORE: 0.7603

RIG_SCORE: 0.7067

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P310H	TCGA-A5-A0G1	UCEC	TCGA	PHTTT	DEG_SPOP_SBC_1	0.7694
p.P310H	DO42472	UCEC	ICGC	PHTTT	DEG_SPOP_SBC_1	0.7694
p.L309I	TCGA-EE-A2GR	SKCM	TCGA	PHTTT	DEG_SPOP_SBC_1	0.3056
p.L309I	DO37996	SKCM	ICGC	PHTTT	DEG_SPOP_SBC_1	0.3056
p.K321T	TCGA-HZ-A4BK	PAAD	TCGA	PHTTT	DEG_SPOP_SBC_1	0.25
p.K321T	DO32781	PAAD	ICGC	PHTTT	DEG_SPOP_SBC_1	0.25
p.E317D	TCGA-XF-A9SM	BLCA	TCGA	PHTTT	DEG_SPOP_SBC_1	0.25
p.E317D	DO223597	BLCA	ICGC	PHTTT	DEG_SPOP_SBC_1	0.25
p.T312S	DO50499	BOCA	ICGC	PHTTT	DEG_SPOP_SBC_1	0.6005
p.K322R	DO233918	GACA	ICGC	PHTTT	DEG_SPOP_SBC_1	0.2222
p.A323T	SIDM00697	Small Cell Lung Carcinoma	GDSC	PHTTT	DEG_SPOP_SBC_1	0.0833
p.A323T	ACH-000830	Lung Cancer	CCLE	PHTTT	DEG_SPOP_SBC_1	0.0833
p.P313L	Hs939-T	skin	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.7582
p.G303S	HEC-1	endometrium	COSMIC	PHTTT	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58EX2	Protein sidekick-2	DEG_SPOP_SBC_1	1512:1516	PHTTT	SPOP	0.9437	More...
Q9BY11	Protein kinase C and casein kinase substrate in neurons protein 1	DEG_SPOP_SBC_1	310:314	PHTTT	SPOP	0.946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons