DegronMD

Uniprot ID: Q58EX2

Source protein: Protein sidekick-2

Source gene: SDK2

Class: DEG_SCF_FBW7_1

Location: 450:457

E3 ligase: FBXW7

DEGRON score: 0.548

ASA_SCORE: 76.4625

COIL: 0.5134

CONS_SCORE: 0.4104

DSS_SCORE: 0.3046

HELIX: 0.0128

FCONS_SCORE: 0.9813

RIG_SCORE: 0.7688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R451H	TCGA-A5-A0G2	UCEC	TCGA	PRFTPLES	DEG_SCF_FBW7_1	0.7133
p.R451H	DO41235	UCEC	ICGC	PRFTPLES	DEG_SCF_FBW7_1	0.7133
p.R440C	TCGA-AA-A01R	COAD	TCGA	PRFTPLES	DEG_SCF_FBW7_1	0.0556
p.R440C	DO7934	COAD	ICGC	PRFTPLES	DEG_SCF_FBW7_1	0.0556
p.S457L	TCGA-EE-A2MS	SKCM	TCGA	PRFTPLES	DEG_SCF_FBW7_1	0.7667
p.S457L	DO233634	GACA	ICGC	PRFTPLES	DEG_SCF_FBW7_1	0.7667
p.S457L	DO37567	SKCM	ICGC	PRFTPLES	DEG_SCF_FBW7_1	0.7667
p.L461H	SIDM00541	Colorectal Carcinoma	GDSC	PRFTPLES	DEG_SCF_FBW7_1	0.2222
p.L461H	ACH-000926	Colon/Colorectal Cancer	CCLE	PRFTPLES	DEG_SCF_FBW7_1	0.2222
p.L461H	HT55	large_intestine	COSMIC	PRFTPLES	DEG_SCF_FBW7_1	0.2222
p.R440H	SIDM00537	Colorectal Carcinoma	GDSC	PRFTPLES	DEG_SCF_FBW7_1	0.0556
p.R440H	ACH-000982	Colon/Colorectal Cancer	CCLE	PRFTPLES	DEG_SCF_FBW7_1	0.0556
p.R440H	ACH-001345	Colon/Colorectal Cancer	CCLE	PRFTPLES	DEG_SCF_FBW7_1	0.0556
p.R440H	GP5d	large_intestine	COSMIC	PRFTPLES	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58EX2	Protein sidekick-2	DEG_SCF_FBW7_1	450:457	PRFTPLES	FBXW7	0.548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons