DegronMD

Uniprot ID: Q58EX2

Source protein: Protein sidekick-2

Source gene: SDK2

Class: CBL_PTK

Location: 2008:2015

E3 ligase: CBL

DEGRON score: 0.9959

ASA_SCORE: 84.725

COIL: 0.924

CONS_SCORE: 0.4618

DSS_SCORE: 0.5427

HELIX: 0.0213

FCONS_SCORE: 0.8981

RIG_SCORE: 0.6634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H2024N	TCGA-AP-A059	UCEC	TCGA	NGLYTRSP	CBL_PTK	0.0833
p.H2024N	DO41361	UCEC	ICGC	NGLYTRSP	CBL_PTK	0.0833
p.R2006Q	TCGA-AX-A0J0	UCEC	TCGA	NGLYTRSP	CBL_PTK	0.2778
p.R2006Q	DO41133	UCEC	ICGC	NGLYTRSP	CBL_PTK	0.2778
p.K2007N	TCGA-N8-A4PL	UCS	TCGA	NGLYTRSP	CBL_PTK	0.3056
p.S2019R	DO229009	LICA	ICGC	NGLYTRSP	CBL_PTK	0.2222
p.P2015A	DO51061	PRAD	ICGC	NGLYTRSP	CBL_PTK	0.7503
p.G2009S	SIDM00380	Acute Myeloid Leukemia	GDSC	NGLYTRSP	CBL_PTK	0.5882
p.G2009S	ACH-000373	Leukemia	CCLE	NGLYTRSP	CBL_PTK	0.5882
p.G2009S	SKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	NGLYTRSP	CBL_PTK	0.5882
p.P2015S	ACH-000937	Leukemia	CCLE	NGLYTRSP	CBL_PTK	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q58EX2	Protein sidekick-2	CBL_PTK	2008:2015	NGLYTRSP	CBL	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons