DegronMD

Uniprot ID: P46100

Source protein: Transcriptional regulator ATRX

Source gene: ATRX

Class: DEG_SPOP_SBC_1

Location: 556:560

E3 ligase: SPOP

DEGRON score: 0.9969

ASA_SCORE: 86.34

COIL: 0.6646

CONS_SCORE: 0.2772

DSS_SCORE: 0.6026

HELIX: 0.2878

FCONS_SCORE: 1.0557

RIG_SCORE: 0.7029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D547N	TCGA-AP-A0LM	UCEC	TCGA	VESSS	DEG_SPOP_SBC_1	0.0833
p.S549N	TCGA-AZ-6598	COAD	TCGA	VESSS	DEG_SPOP_SBC_1	0.5833
p.G564D	DO1285	BRCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.L552I	DO222986	BTCA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.L552I	DO228881	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.S558F	DO51624	CESC	ICGC	VESSS	DEG_SPOP_SBC_1	0.7982
p.E547K	DO8730	COAD	ICGC	VESSS	DEG_SPOP_SBC_1	0.0833
p.Q568K	DO229031	LICA	ICGC	VESSS	DEG_SPOP_SBC_1	0.5556
p.V570F	DO26590	LUSC	ICGC	VESSS	DEG_SPOP_SBC_1	0.0556
p.S560F	DO51699	PAAD	ICGC	VESSS	DEG_SPOP_SBC_1	0.7982
p.G564C	DO43907	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.2222
p.E569D	DO41458	UCEC	ICGC	VESSS	DEG_SPOP_SBC_1	0.0833
p.N564S	SIDM01189	Glioblastoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.2222
p.N564S	ACH-000075	Brain Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.2222
p.N564S	U-87-MG	central_nervous_system	COSMIC	VESSS	DEG_SPOP_SBC_1	0.2222
p.S550T	SIDM00203	Ewing's Sarcoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.6111
p.S550T	ACH-002111	Bone Cancer	CCLE	VESSS	DEG_SPOP_SBC_1	0.6111
p.S550T	EW-11	bone	COSMIC	VESSS	DEG_SPOP_SBC_1	0.6111
p.G551V	SIDM00265	Ewing's Sarcoma	GDSC	VESSS	DEG_SPOP_SBC_1	0.1944
p.G551V	ES3	bone	COSMIC	VESSS	DEG_SPOP_SBC_1	0.1944
p.L557F	COLO-783	skin	COSMIC	VESSS	DEG_SPOP_SBC_1	0.6981
p.Q568E	HCC38	breast	COSMIC	VESSS	DEG_SPOP_SBC_1	0.5556
p.P554H	CW-2	large_intestine	COSMIC	VESSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P38398	Breast cancer type 1 susceptibility protein	DEG_SPOP_SBC_1	764:768	VESSS	SPOP	0.9922	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	556:560	VESSS	SPOP	0.9969	More...
Q16236	Nuclear factor erythroid 2-related factor 2	DEG_SPOP_SBC_1	361:365	VESSS	SPOP	0.9641	More...
Q58EX7	Puratrophin-1	DEG_SPOP_SBC_1	87:91	VESSS	SPOP	0.97	More...
Q6ZW76	Ankyrin repeat and SAM domain-containing protein 3	DEG_SPOP_SBC_1	327:331	VESSS	SPOP	0.9989	More...
Q86XP1	Diacylglycerol kinase eta	DEG_SPOP_SBC_1	584:588	VESSS	SPOP	0.7501	More...
Q8N108	Mesoderm induction early response protein 1	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.7443	More...
Q8N5B7	Ceramide synthase 5	DEG_SPOP_SBC_1	352:356	VESSS	SPOP	0.6322	More...
Q8NEM8	Cytosolic carboxypeptidase 3	DEG_SPOP_SBC_1	611:615	VESSS	SPOP	0.7484	More...
Q8NFG4	Folliculin	DEG_SPOP_SBC_1	69:73	VESSS	SPOP	0.5048	More...
Q9H4Z2	Zinc finger protein 335	DEG_SPOP_SBC_1	6:10	VESSS	SPOP	0.5869	More...
Q9P272	Probable tRNA methyltransferase 9B	DEG_SPOP_SBC_1	313:317	VESSS	SPOP	0.7748	More...
Q9UHY1	Nuclear receptor-binding protein	DEG_SPOP_SBC_1	18:22	VESSS	SPOP	0.9939	More...
Q8NCQ7	Protein PROCA1	DEG_SPOP_SBC_1	323:327	VESSS	SPOP	0.5806	More...
Q9H158	Protocadherin alpha-C1	DEG_SPOP_SBC_1	500:504	VESSS	SPOP	0.5524	More...
Q5TG30	Rho GTPase-activating protein 40	DEG_SPOP_SBC_1	24:28	VESSS	SPOP	0.9601	More...
Q8NDA8	Maestro heat-like repeat-containing protein family member 1	DEG_SPOP_SBC_1	321:325	VESSS	SPOP	0.5715	More...
A8MU93	Uncharacterized protein C17orf100	DEG_SPOP_SBC_1	71:75	VESSS	SPOP	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VESSS

Degron related mutations and impact score

Drug responses associated with ATRX mutations

All proteins holding degron of VESSS