DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPEIE
Uniprot ID:
Q9UI36
Source protein:
Dachshund homolog 1
Source gene:
DACH1
Class:
DEG_SCF_FBW7_2
Location:
726:731
E3 ligase:
FBXW7
DEGRON score:
0.9981
ASA_SCORE:
79.4833
COIL:
0.5797
CONS_SCORE:
0.5077
DSS_SCORE:
0.5415
HELIX:
0.3957
FCONS_SCORE:
1.1892
RIG_SCORE:
0.7212
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A732D
SAS
upper_aerodigestive_tract
COSMIC
LTPEIE
DEG_SCF_FBW7_2
0.3056
p.S735N
HCT-15
large_intestine
COSMIC
LTPEIE
DEG_SCF_FBW7_2
0.6667
Drug responses associated with DACH1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LTPEIE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UI36
Dachshund homolog 1
DEG_SCF_FBW7_2
726:731
LTPEIE
FBXW7
0.9981
More...