DegronMD

Uniprot ID: Q9UI36

Source protein: Dachshund homolog 1

Source gene: DACH1

Class: DEG_APCC_DBOX_1

Location: 585:593

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6312

ASA_SCORE: 73.7333

COIL: 0.5828

CONS_SCORE: 0.374

DSS_SCORE: 0.6384

HELIX: 0.3873

FCONS_SCORE: 0.9495

RIG_SCORE: 0.6939

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q594K	TCGA-09-2044	OV	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	0.3056
p.K601N	TCGA-22-5480	LUSC	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	0.1111
p.V593I	TCGA-CG-5721	STAD	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	0.7076
p.D603N	TCGA-ER-A19O	SKCM	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	0.0556
p.D603G	TCGA-FI-A2D5	UCEC	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	0.0556
p.E596K	TCGA-FS-A1ZA	SKCM	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	0.25
p.D584H	TCGA-GC-A4ZW	BLCA	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	0.75
p.G577R	TCGA-MQ-A4LM	MESO	TCGA	ARDSLDKLS	DEG_APCC_DBOX_1	0.1111
p.P583A	WM278	skin	COSMIC	ARDSLDKLS	DEG_APCC_DBOX_1	0.2778
p.T582I	HCC1954	breast	COSMIC	ARDSLDKLS	DEG_APCC_DBOX_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UI36	Dachshund homolog 1	DEG_APCC_DBOX_1	585:593	ARDSLDKLS	APC,CDC20,FZR1	0.6312	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons