DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ANSTT
Uniprot ID:
Q7Z2G1
Source protein:
Histone H2B type W-T
Source gene:
H2BW1
Class:
DEG_SPOP_SBC_1
Location:
50:54
E3 ligase:
SPOP
DEGRON score:
0.8915
ASA_SCORE:
88.94
COIL:
0.8838
CONS_SCORE:
0.3949
DSS_SCORE:
0.7661
HELIX:
0.094
FCONS_SCORE:
1.1016
RIG_SCORE:
0.6074
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T44A
SIDM00151
Ovarian Carcinoma
GDSC
ANSTT
DEG_SPOP_SBC_1
0.1667
p.P47S
SIDM01051
Ovarian Carcinoma
GDSC
ANSTT
DEG_SPOP_SBC_1
0.25
Drug responses associated with H2BW1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ANSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94876
Transmembrane and coiled-coil domains protein 1
DEG_SPOP_SBC_1
433:437
ANSTT
SPOP
0.6609
More...
Q15059
Bromodomain-containing protein 3
DEG_SPOP_SBC_1
540:544
ANSTT
SPOP
0.9782
More...
Q86TC9
Myopalladin
DEG_SPOP_SBC_1
547:551
ANSTT
SPOP
0.9532
More...
Q96T58
Msx2-interacting protein
DEG_SPOP_SBC_1
1569:1573
ANSTT
SPOP
0.992
More...
Q7Z2G1
Histone H2B type W-T
DEG_SPOP_SBC_1
50:54
ANSTT
SPOP
0.8915
More...