DegronMD

Uniprot ID: Q86TC9

Source protein: Myopalladin

Source gene: MYPN

Class: DEG_SCF_FBW7_2

Location: 920:927

E3 ligase: FBXW7

DEGRON score: 0.6658

ASA_SCORE: 93.2375

COIL: 0.6869

CONS_SCORE: 0.6979

DSS_SCORE: 0.4869

HELIX: 0.1619

FCONS_SCORE: 1.0939

RIG_SCORE: 0.7348

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L912Q	TCGA-43-2581	LUSC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.1111
p.R919C	TCGA-A5-A2K5	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919C	TCGA-AJ-A5DW	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919C	DO44093	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919C	ACH-002509	Skin Cancer	CCLE	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R922H	TCGA-A6-2686	COAD	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.7133
p.R919H	TCGA-AZ-6608	COAD	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	TCGA-B5-A3FC	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	DO10550	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	DO26590	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	MHH-NB-11	autonomic_ganglia	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R922C	TCGA-B5-A3FA	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.719
p.R922C	TCGA-BA-5151	HNSC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.719
p.E917D	TCGA-B6-A0I9	BRCA	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.25
p.E915K	TCGA-FR-A8YC	SKCM	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.1944
p.M913V	TCGA-HU-A4H4	STAD	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.1389
p.E936K	TCGA-Z6-A8JE	ESCA	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.0833
p.E910K	DO220823	BRCA	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.0556
p.P924S	DO10510	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.6752
p.R919G	DO230538	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.E917Q	DO26520	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.25
p.T936S	DO229155	NKTL	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.0833
p.P913L	DO218904	SKCA	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.1389
p.P924L	DO37567	SKCM	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.7582
p.D933E	DO51777	STAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.1667
p.K932T	DO41235	UCEC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.1944
p.T931A	SNU-C5	large_intestine	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.2222
p.I921L	HCT-15	large_intestine	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.7174
p.R922K	639-V	urinary_tract	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.6126
p.T917I	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.25
p.T936I	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.0833
p.P913H	NCI-H1703	lung	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LERTPVDE

Degron related mutations and impact score

Drug responses associated with MYPN mutations

All proteins holding degron of LERTPVDE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TC9	Myopalladin	DEG_SCF_FBW7_2	920:927	LERTPVDE	FBXW7	0.6658	More...