DegronMD

Uniprot ID: Q86TC9

Source protein: Myopalladin

Source gene: MYPN

Class: DEG_SCF_FBW7_2

Location: 920:927

E3 ligase: FBXW7

DEGRON score: 0.6658

ASA_SCORE: 93.2375

COIL: 0.6869

CONS_SCORE: 0.6979

DSS_SCORE: 0.4869

HELIX: 0.1619

FCONS_SCORE: 1.0939

RIG_SCORE: 0.7348

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P924L	DO37567	SKCM	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.7582
p.R922C	TCGA-B5-A3FA	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.719
p.R922C	TCGA-BA-5151	HNSC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.719
p.I921L	HCT-15	large_intestine	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.7174
p.R922H	TCGA-A6-2686	COAD	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.7133
p.P924S	DO10510	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.6752
p.R922K	639-V	urinary_tract	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.6126
p.R919C	TCGA-A5-A2K5	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919C	TCGA-AJ-A5DW	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919C	DO44093	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919C	ACH-002509	Skin Cancer	CCLE	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919C	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	TCGA-AZ-6608	COAD	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	TCGA-B5-A3FC	UCEC	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	DO10550	COAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	DO26590	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919H	MHH-NB-11	autonomic_ganglia	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.R919G	DO230538	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.3056
p.E917D	TCGA-B6-A0I9	BRCA	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.25
p.E917Q	DO26520	LUSC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.25
p.T917I	SU-DHL-6	haematopoietic_and_lymphoid_tissue	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.25
p.T931A	SNU-C5	large_intestine	COSMIC	LERTPVDE	DEG_SCF_FBW7_2	0.2222
p.E915K	TCGA-FR-A8YC	SKCM	TCGA	LERTPVDE	DEG_SCF_FBW7_2	0.1944
p.K932T	DO41235	UCEC	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.1944
p.D933E	DO51777	STAD	ICGC	LERTPVDE	DEG_SCF_FBW7_2	0.1667

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Drug responses associated with MYPN mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LERTPVDE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86TC9	Myopalladin	DEG_SCF_FBW7_2	920:927	LERTPVDE	FBXW7	0.6658	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LERTPVDE

Degron related mutations and impact score

Drug responses associated with MYPN mutations

All proteins holding degron of LERTPVDE