DegronMD

Uniprot ID: Q86TC9

Source protein: Myopalladin

Source gene: MYPN

Class: DEG_SPOP_SBC_1

Location: 702:706

E3 ligase: SPOP

DEGRON score: 0.7279

ASA_SCORE: 69.62

COIL: 0.6364

CONS_SCORE: 0.3111

DSS_SCORE: 0.5214

HELIX: 0.0458

FCONS_SCORE: 0.911

RIG_SCORE: 0.691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P713S	TCGA-16-0849	GBM	TCGA	AVTTS	DEG_SPOP_SBC_1	0.1389
p.P700S	TCGA-A2-A0CL	BRCA	TCGA	AVTTS	DEG_SPOP_SBC_1	0.2778
p.P700S	SIDM00040	Gastric Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.2778
p.P700S	ACH-002202	Gastric Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	0.2778
p.P700S	TMK-1	stomach	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.2778
p.A699D	TCGA-EI-6514	READ	TCGA	AVTTS	DEG_SPOP_SBC_1	0.25
p.K708N	DO229018	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.2778
p.Q709H	DO229022	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.25
p.W703L	DO229022	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7015
p.F704Y	DO222363	MELA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7528
p.G695V	DO37447	SKCM	ICGC	AVTTS	DEG_SPOP_SBC_1	0.1389
p.G695W	DO50279	SKCM	ICGC	AVTTS	DEG_SPOP_SBC_1	0.1389
p.D706Y	DO41020	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7325
p.R713I	DO41488	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	0.1389
p.N698S	SIDM00234	Other Solid Cancers	GDSC	AVTTS	DEG_SPOP_SBC_1	0.2222
p.N698S	TC-YIK	cervix	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.2222
p.K705E	LCLC-97TM1	lung	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E9	GTP-binding protein 10	DEG_SPOP_SBC_1	378:382	AVTTS	SPOP	0.8328	More...
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_SPOP_SBC_1	773:777	AVTTS	SPOP	0.9929	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2240:2244	AVTTS	SPOP	0.9879	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	906:910	AVTTS	SPOP	0.9012	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	702:706	AVTTS	SPOP	0.7279	More...
Q8TEW8	Partitioning defective 3 homolog B	DEG_SPOP_SBC_1	616:620	AVTTS	SPOP	0.734	More...
Q9UKM9	RNA-binding protein Raly	DEG_SPOP_SBC_1	172:176	AVTTS	SPOP	0.9427	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	422:426	AVTTS	SPOP	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons