DegronMD - Q9UKM9(RALY)

FUNCTION: RNA-binding protein that acts as a transcriptional cofactor for cholesterol biosynthetic genes in the liver. Binds the lipid-responsive non-coding RNA LeXis and is required for LeXis-mediated effect on cholesterogenesis (By similarity). May be a heterogeneous nuclear ribonucleoprotein (hnRNP) (PubMed:9376072). {ECO:0000250|UniProtKB:Q64012, ECO:0000269|PubMed:9376072}.

GO - Biological processes (BP): cholesterol homeostasis [GO:0042632]; mRNA splicing, via spliceosome [GO:0000398]; regulation of nucleic acid-templated transcription [GO:1903506]

GO - Molecular function (MF): RNA binding [GO:0003723]; transcription coregulator activity [GO:0003712]

GO - Cellular component (CC): catalytic step 2 spliceosome [GO:0071013]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R131W	TCGA-A5-A1OF	UCEC	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8634
p.R131L	DO228974	LICA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8428
p.K130M	DO32327	OV	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8062
p.S135L	TCGA-AD-6895	COAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7667
p.R133W	DO38795	STAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7523
p.R133L	DO37465	SKCM	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7316
p.E170K	DO558	BLCA	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation blocking phosphorylation signal	0.7222
p.P132T	NCI-H3122	lung	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7031
p.L134V	TCGA-L5-A8NR	ESCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6765
p.R133G	DO18602	KIRC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6457
p.G132V	TCGA-EB-A299	SKCM	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6421
p.V137M	TCGA-VQ-A8PB	STAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6097
p.P136T	TCGA-BH-A0BZ	BRCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.5919
p.S183F	DO44881	LIHC	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation blocking ubiquitination signal	0.5833
p.K146M	TCGA-23-2647	OV	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation blocking ubiquitination signal	0.5556
p.L171M	DO233764	GACA	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.L171M	DO229055	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.I181V	DO22237	LGG	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation substituting flanking lysine	0.3056
p.V139M	SIDM00393	Gastric Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.3056
p.V139M	SIDM01039	Other Solid Cancers	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 47 entries

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Kaplan plot for RALY in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

RALY

UniProt ID: Q9UKM9

Entrez ID: 22913

Protein name: RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RALY in