DegronMD - Q9UKM9(RALY)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K146M	TCGA-23-2647	OV	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation blocking ubiquitination signal	0.5556
p.R131W	TCGA-A5-A1OF	UCEC	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8634
p.S135L	TCGA-AD-6895	COAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7667
p.D122N	TCGA-AQ-A0Y5	BRCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1111
p.D122N	DO5738	BRCA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1111
p.P136T	TCGA-BH-A0BZ	BRCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.5919
p.D125N	TCGA-BR-8483	STAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1944
p.D125N	TCGA-G4-6310	COAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1944
p.D125N	DO9442	COAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1944
p.D125N	DO47821	STAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1944
p.E186K	TCGA-DK-A1A3	BLCA	TCGA	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.0556
p.G132V	TCGA-EB-A299	SKCM	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6421
p.R120W	TCGA-EE-A17X	SKCM	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.R120W	DO37931	SKCM	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.A142V	TCGA-FI-A2D5	UCEC	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.2222
p.F123L	TCGA-L5-A8NR	ESCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.1389
p.L134V	TCGA-L5-A8NR	ESCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6765
p.V137M	TCGA-VQ-A8PB	STAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6097
p.E170K	DO558	BLCA	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation blocking phosphorylation signal	0.7222
p.P120T	DO1396	BRCA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.L171M	DO233764	GACA	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.L171M	DO229055	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.3056
p.P128S	DO233944	GACA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.2778
p.R133G	DO18602	KIRC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.6457
p.I181V	DO22237	LGG	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation substituting flanking lysine	0.3056
p.R131L	DO228974	LICA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8428
p.S183F	DO44881	LIHC	ICGC	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation blocking ubiquitination signal	0.5833
p.K130M	DO32327	OV	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.8062
p.R133L	DO37465	SKCM	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7316
p.V121M	DO51766	STAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0833
p.V121M	DO43763	UCEC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0833
p.R133W	DO38795	STAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7523
p.R141C	DO42504	UCEC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.25
p.A126V	DO41331	UCEC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.2222
p.V139M	SIDM00393	Gastric Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.3056
p.V139M	SIDM01039	Other Solid Cancers	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.3056
p.V139M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.3056
p.V139M	SIDM00863	Burkitt's Lymphoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.3056
p.V139M	SIDM01318	Hepatocellular Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.3056
p.P148T	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.P148T	ACH-000337	Lung Cancer	CCLE	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.P148T	NCI-H3122	lung	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.0556
p.R169H	ACH-000088	Non-Cancerous	CCLE	AVTTS	DEG_SPOP_SBC_1	172:176	Mutation rewiring degron network	0.25
p.P132T	NCI-H3122	lung	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation altering degron motif	0.7031
p.R141P	RCC-FG2	kidney	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.25
p.R140W	NCI-H747	large intestine	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.2778
p.R140Q	SN12C	kidney	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	130:138	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RALY

UniProt ID: Q9UKM9

Entrez ID: 22913

Protein name: RNA-binding protein Raly (Autoantigen p542) (Heterogeneous nuclear ribonucleoprotein C-like 2) (hnRNP core protein C-like 2) (hnRNP associated with lethal yellow protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RALY in