DegronMD

Uniprot ID: Q9UKM9

Source protein: RNA-binding protein Raly

Source gene: RALY

Class: DEG_APCC_DBOX_1

Location: 130:138

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8588

ASA_SCORE: 83.2889

COIL: 0.843

CONS_SCORE: 0.4599

DSS_SCORE: 0.1502

HELIX: 0.0651

FCONS_SCORE: 1.0907

RIG_SCORE: 0.7791

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K146M	TCGA-23-2647	OV	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.5556
p.R131W	TCGA-A5-A1OF	UCEC	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.8634
p.S135L	TCGA-AD-6895	COAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.7667
p.D122N	TCGA-AQ-A0Y5	BRCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.1111
p.D122N	DO5738	BRCA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.1111
p.P136T	TCGA-BH-A0BZ	BRCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.5919
p.D125N	TCGA-BR-8483	STAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.1944
p.D125N	TCGA-G4-6310	COAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.1944
p.D125N	DO9442	COAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.1944
p.D125N	DO47821	STAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.1944
p.G132V	TCGA-EB-A299	SKCM	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.6421
p.R120W	TCGA-EE-A17X	SKCM	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.0556
p.R120W	DO37931	SKCM	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.0556
p.A142V	TCGA-FI-A2D5	UCEC	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.2222
p.F123L	TCGA-L5-A8NR	ESCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.1389
p.L134V	TCGA-L5-A8NR	ESCA	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.6765
p.V137M	TCGA-VQ-A8PB	STAD	TCGA	YRGRLSPVP	DEG_APCC_DBOX_1	0.6097
p.P120T	DO1396	BRCA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.0556
p.P128S	DO233944	GACA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.2778
p.R133G	DO18602	KIRC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.6457
p.R131L	DO228974	LICA	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.8428
p.K130M	DO32327	OV	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.8062
p.R133L	DO37465	SKCM	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.7316
p.V121M	DO51766	STAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.0833
p.V121M	DO43763	UCEC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.0833
p.R133W	DO38795	STAD	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.7523
p.R141C	DO42504	UCEC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.25
p.A126V	DO41331	UCEC	ICGC	YRGRLSPVP	DEG_APCC_DBOX_1	0.2222
p.V139M	SIDM00393	Gastric Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	0.3056
p.V139M	SIDM01039	Other Solid Cancers	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	0.3056
p.V139M	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	0.3056
p.V139M	SIDM00863	Burkitt's Lymphoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	0.3056
p.V139M	SIDM01318	Hepatocellular Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	0.3056
p.P148T	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	YRGRLSPVP	DEG_APCC_DBOX_1	0.0556
p.P148T	ACH-000337	Lung Cancer	CCLE	YRGRLSPVP	DEG_APCC_DBOX_1	0.0556
p.P148T	NCI-H3122	lung	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	0.0556
p.P132T	NCI-H3122	lung	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	0.7031
p.R141P	RCC-FG2	kidney	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	0.25
p.R140W	NCI-H747	large_intestine	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	0.2778
p.R140Q	SN12C	kidney	COSMIC	YRGRLSPVP	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: YRGRLSPVP

Degron related mutations and impact score

Drug responses associated with RALY mutations

All proteins holding degron of YRGRLSPVP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKM9	RNA-binding protein Raly	DEG_APCC_DBOX_1	130:138	YRGRLSPVP	APC,CDC20,FZR1	0.8588	More...