DegronMD

Uniprot ID: A4D1E9

Source protein: GTP-binding protein 10

Source gene: GTPBP10

Class: DEG_SPOP_SBC_1

Location: 378:382

E3 ligase: SPOP

DEGRON score: 0.8328

ASA_SCORE: 52.38

COIL: 0.3894

CONS_SCORE: 0.2135

DSS_SCORE: 0.6777

HELIX: 0.0612

FCONS_SCORE: 0.9934

RIG_SCORE: 0.7383

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A378D	TCGA-AP-A051	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	0.7793
p.A378D	DO42673	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7793
p.M368I	DO228483	BRCA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.0556
p.M368I	DO229013	COCA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.0556
p.M368I	DO234205	ESAD	ICGC	AVTTS	DEG_SPOP_SBC_1	0.0556
p.M368I	DO229047	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E9	GTP-binding protein 10	DEG_SPOP_SBC_1	378:382	AVTTS	SPOP	0.8328	More...
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_SPOP_SBC_1	773:777	AVTTS	SPOP	0.9929	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2240:2244	AVTTS	SPOP	0.9879	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	906:910	AVTTS	SPOP	0.9012	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	702:706	AVTTS	SPOP	0.7279	More...
Q8TEW8	Partitioning defective 3 homolog B	DEG_SPOP_SBC_1	616:620	AVTTS	SPOP	0.734	More...
Q9UKM9	RNA-binding protein Raly	DEG_SPOP_SBC_1	172:176	AVTTS	SPOP	0.9427	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	422:426	AVTTS	SPOP	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons