DegronMD

Uniprot ID: O15042

Source protein: U2 snRNP-associated SURP motif-containing protein

Source gene: U2SURP

Class: DEG_APCC_DBOX_1

Location: 538:546

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5743

ASA_SCORE: 52.4

COIL: 0.0113

CONS_SCORE: 0.6123

DSS_SCORE: 0.4517

HELIX: 0.9882

FCONS_SCORE: 1.3765

RIG_SCORE: 0.8078

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R539K	TCGA-21-1083	LUSC	TCGA	QRDKLEEIL	DEG_APCC_DBOX_1	0.7237
p.S529C	TCGA-64-1676	LUAD	TCGA	QRDKLEEIL	DEG_APCC_DBOX_1	0.0833
p.T550S	TCGA-BS-A0U8	UCEC	TCGA	QRDKLEEIL	DEG_APCC_DBOX_1	0.2222
p.D555H	TCGA-LL-A73Y	BRCA	TCGA	QRDKLEEIL	DEG_APCC_DBOX_1	0.0833
p.R534Q	DO9002	COAD	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.2222
p.R534Q	DO41211	UCEC	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.2222
p.R528H	DO13252	GBM	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.0556
p.R528C	DO229052	LICA	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.0556
p.S542L	DO220891	MELA	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.7667
p.S542L	DO36368	PRAD	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.7667
p.S542L	DO51292	SKCM	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.7667
p.S545L	DO229456	SKCA	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.7667
p.P540S	DO47837	STAD	ICGC	QRDKLEEIL	DEG_APCC_DBOX_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_APCC_DBOX_1	538:546	QRDKLEEIL	APC,CDC20,FZR1	0.5743	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons