DegronMD

Uniprot ID: Q9H0E3

Source protein: Histone deacetylase complex subunit SAP130

Source gene: SAP130

Class: DEG_APCC_DBOX_1

Location: 452:460

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8486

ASA_SCORE: 94.7667

COIL: 0.8908

CONS_SCORE: 0.3933

DSS_SCORE: 0.6089

HELIX: 0.0317

FCONS_SCORE: 0.8717

RIG_SCORE: 0.6576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E452K	TCGA-D5-5541	COAD	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	0.591
p.P458S	TCGA-EE-A2MR	SKCM	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	0.5641
p.S460F	TCGA-FW-A3R5	SKCM	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	0.7982
p.P458T	TCGA-G2-A2EO	BLCA	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	0.5919
p.A470T	TCGA-XC-AA0X	LUSC	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	0.0556
p.A470T	SIDM00217	Colorectal Carcinoma	GDSC	ERSSLIPIS	DEG_APCC_DBOX_1	0.0556
p.A470T	SNU-1040	large_intestine	COSMIC	ERSSLIPIS	DEG_APCC_DBOX_1	0.0556
p.F459L	DO1158	BRCA	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	0.6981
p.F459L	DO228974	LICA	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	0.6981
p.A444T	DO52026	LUSC	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	0.1111
p.A444T	ACH-000999	Colon/Colorectal Cancer	CCLE	ERSSLIPIS	DEG_APCC_DBOX_1	0.1111
p.A444T	SNU-1040	large_intestine	COSMIC	ERSSLIPIS	DEG_APCC_DBOX_1	0.1111
p.Q460H	DO51766	STAD	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	0.7582
p.F462L	DO42793	UCEC	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	0.2778
p.R444W	SIDM00962	Chronic Myelogenous Leukemia	GDSC	ERSSLIPIS	DEG_APCC_DBOX_1	0.1111
p.R444W	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	ERSSLIPIS	DEG_APCC_DBOX_1	0.1111
p.D448N	SIDM00660	Colorectal Carcinoma	GDSC	ERSSLIPIS	DEG_APCC_DBOX_1	0.2222
p.D448N	LS-411N	large_intestine	COSMIC	ERSSLIPIS	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_APCC_DBOX_1	452:460	ERSSLIPIS	APC,CDC20,FZR1	0.8486	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons