DegronMD

Uniprot ID: Q9H0E3

Source protein: Histone deacetylase complex subunit SAP130

Source gene: SAP130

Class: DEG_SCF_FBW7_1

Location: 748:755

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 99.55

COIL: 0.9704

CONS_SCORE: 0.3549

DSS_SCORE: 0.3482

HELIX: 0.0076

FCONS_SCORE: 0.8749

RIG_SCORE: 0.755

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q743H	TCGA-E9-A1NC	BRCA	TCGA	VPITPPIT	DEG_SCF_FBW7_1	0.1944
p.P760S	TCGA-FR-A3YN	SKCM	TCGA	VPITPPIT	DEG_SCF_FBW7_1	0.1944
p.P757L	TCGA-RD-A7C1	STAD	TCGA	VPITPPIT	DEG_SCF_FBW7_1	0.2778
p.S750P	DO223477	CLLE	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.6752
p.P742L	DO8834	COAD	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.1667
p.Q744K	DO229041	LICA	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.2222
p.P742S	DO26842	LUSC	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.1667
p.A755V	DO232761	PBCA	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.6936
p.A755V	DO222342	STAD	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.6936
p.P741L	DO50284	SKCM	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.1389
p.P741S	DO47331	SKCM	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.1389
p.I758V	DO42568	UCEC	ICGC	VPITPPIT	DEG_SCF_FBW7_1	0.25
p.V748F	SIDM01682	Gastric Carcinoma	GDSC	VPITPPIT	DEG_SCF_FBW7_1	0.7068
p.A755T	ACH-000450	Skin Cancer	CCLE	VPITPPIT	DEG_SCF_FBW7_1	0.7139
p.A755T	MEL-HO	skin	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	0.7139
p.P745Q	ACH-000792	Kidney Cancer	CCLE	VPITPPIT	DEG_SCF_FBW7_1	0.25
p.P745Q	BFTC-909	kidney	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	0.25
p.A756T	MEL-HO	skin	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	0.3056
p.P746Q	BFTC-909	kidney	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	0.2778
p.A747T	MEL-HO	skin	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SCF_FBW7_1	748:755	VPITPPIT	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons