DegronMD

Uniprot ID: Q2NKQ1

Source protein: Small G protein signaling modulator 1

Source gene: SGSM1

Class: DEG_SCF_TRCP1_1

Location: 766:772

E3 ligase: BTRC

DEGRON score: 0.9823

ASA_SCORE: 65.7429

COIL: 0.8364

CONS_SCORE: 0.2879

DSS_SCORE: 0.6482

HELIX: 0.0616

FCONS_SCORE: 1.0998

RIG_SCORE: 0.5076

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G756W	TCGA-AP-A056	UCEC	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	0.0556
p.G756W	DO43971	UCEC	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.0556
p.H769Y	TCGA-D3-A51G	SKCM	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	0.6118
p.H769Y	DO47700	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.6118
p.G761S	TCGA-D5-6530	COAD	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	0.1944
p.G761S	DO8312	COAD	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.1944
p.L779F	TCGA-EB-A51B	SKCM	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	0.1389
p.L779F	DO47343	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.1389
p.S764F	TCGA-FW-A3R5	SKCM	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	0.2778
p.S764F	DO37406	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.2778
p.D780N	DO229177	LMS	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.1111
p.S776F	DO222521	MELA	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.2222
p.E774K	DO37444	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.2778
p.Q768K	DO38011	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.6944
p.R773Q	DO41361	UCEC	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	0.3056
p.P770S	SIDM00007	Other Solid Cancers	GDSC	DSGHPSS	DEG_SCF_TRCP1_1	0.5641
p.P770S	MCC13	skin	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	0.5641
p.R773W	ACH-000190	Unknown	CCLE	DSGHPSS	DEG_SCF_TRCP1_1	0.3056
p.R773W	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	0.3056
p.D757Y	ACH-000963	Colon/Colorectal Cancer	CCLE	DSGHPSS	DEG_SCF_TRCP1_1	0.0833
p.D757Y	CCK-81	large_intestine	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	0.0833
p.E763K	ACH-002180	Cervical Cancer	CCLE	DSGHPSS	DEG_SCF_TRCP1_1	0.25
p.E763K	OMC-1	cervix	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	0.25
p.E757K	OMC-1	cervix	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	0.0833
p.R767W	HD-MY-Z	haematopoietic_and_lymphoid_tissue	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2NKQ1	Small G protein signaling modulator 1	DEG_SCF_TRCP1_1	766:772	DSGHPSS	BTRC	0.9823	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons