DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_SPOP_SBC_1

Location: 2893:2897

E3 ligase: SPOP

DEGRON score: 0.9847

ASA_SCORE: 79.46

COIL: 0.772

CONS_SCORE: 0.5967

DSS_SCORE: 0.4282

HELIX: 0.0348

FCONS_SCORE: 1.1073

RIG_SCORE: 0.6322

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2888S	TCGA-EE-A29L	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1944
p.P2888S	TCGA-FS-A1ZZ	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1944
p.P2888S	TCGA-W3-AA1R	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1944
p.P2888S	DO37835	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.P2888S	DO37412	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.P2888S	DO51275	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.G2890R	TCGA-EE-A2GB	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.25
p.G2890R	DO222683	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.G2890R	DO37417	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.V2894G	TCGA-HU-A4GN	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V2894G	DO47833	STAD	ICGC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.T2898A	TCGA-OR-A5L2	ACC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.3056
p.V2907L	DO229031	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0556
p.V2907E	DO23130	LINC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0556
p.P2888L	DO229459	SKCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.P2899H	DO231286	THCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.P2884L	SIDM00672	Hepatocellular Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM01265	Plasma Cell Myeloma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM00773	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM00203	Ewing's Sarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM00032	Bladder Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM00793	Burkitt's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM00224	Mesothelioma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P2884L	SIDM01318	Hepatocellular Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.S2905F	SIDM00857	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1111
p.S2905F	ACH-000572	Skin Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	0.1111
p.S2905F	G-361	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.1111
p.P2899S	SIDM00845	Burkitt's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.P2899S	SIDM01099	Neuroblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.P2899S	SIDM00493	Other Solid Cancers	GDSC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.P2899S	SIDM01147	Gastric Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.S2897C	SIDM01587	Bladder Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.7541
p.S2897C	ACH-000753	Bladder Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60381	HMG box-containing protein 1	DEG_SPOP_SBC_1	154:158	PVSSS	SPOP	0.9698	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	380:384	PVSSS	SPOP	0.8257	More...
P07196	Neurofilament light polypeptide	DEG_SPOP_SBC_1	46:50	PVSSS	SPOP	0.8899	More...
P19793	Retinoic acid receptor RXR-alpha	DEG_SPOP_SBC_1	100:104	PVSSS	SPOP	0.9322	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	599:603	PVSSS	SPOP	0.9897	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1234:1238	PVSSS	SPOP	0.8806	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	869:873	PVSSS	SPOP	0.7599	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	567:571	PVSSS	SPOP	0.8885	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	590:594	PVSSS	SPOP	0.8983	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1009:1013	PVSSS	SPOP	0.7108	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1582:1586	PVSSS	SPOP	0.9597	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1810:1814	PVSSS	SPOP	0.9944	More...
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SPOP_SBC_1	2893:2897	PVSSS	SPOP	0.9847	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	916:920	PVSSS	SPOP	0.9081	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	631:635	PVSSS	SPOP	0.9929	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	588:592	PVSSS	SPOP	0.6309	More...
Q6ZN04	RNA-binding protein MEX3B	DEG_SPOP_SBC_1	391:395	PVSSS	SPOP	0.9174	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	593:597	PVSSS	SPOP	0.7583	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1237:1241	PVSSS	SPOP	0.926	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	1586:1590	PVSSS	SPOP	0.8722	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	97:101	PVSSS	SPOP	0.8909	More...
Q8NDF8	Terminal nucleotidyltransferase 4B	DEG_SPOP_SBC_1	445:449	PVSSS	SPOP	0.9935	More...
Q8NEY1	Neuron navigator 1	DEG_SPOP_SBC_1	693:697	PVSSS	SPOP	0.9862	More...
Q92613	Protein Jade-3	DEG_SPOP_SBC_1	6:10	PVSSS	SPOP	0.9389	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	891:895	PVSSS	SPOP	0.9523	More...
Q9C0C6	CLOCK-interacting pacemaker	DEG_SPOP_SBC_1	245:249	PVSSS	SPOP	0.9936	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1701:1705	PVSSS	SPOP	0.996	More...
Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	DEG_SPOP_SBC_1	369:373	PVSSS	SPOP	0.8095	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	1122:1126	PVSSS	SPOP	0.992	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	977:981	PVSSS	SPOP	0.9676	More...
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	DEG_SPOP_SBC_1	1245:1249	PVSSS	SPOP	0.9694	More...
A0AUZ9	KAT8 regulatory NSL complex subunit 1-like protein	DEG_SPOP_SBC_1	208:212	PVSSS	SPOP	0.5228	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	306:310	PVSSS	SPOP	0.9847	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	446:450	PVSSS	SPOP	0.94	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	481:485	PVSSS	SPOP	0.9669	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	337:341	PVSSS	SPOP	0.9791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSSS

Degron related mutations and impact score

Drug responses associated with SPEG mutations

All proteins holding degron of PVSSS