DegronMD

Uniprot ID: O60732

Source protein: Melanoma-associated antigen C1

Source gene: MAGEC1

Class: DEG_SPOP_SBC_1

Location: 446:450

E3 ligase: SPOP

DEGRON score: 0.94

ASA_SCORE: 80.1

COIL: 0.9448

CONS_SCORE: 0.4048

DSS_SCORE: 0.2013

HELIX: 0.0286

FCONS_SCORE: 1.0001

RIG_SCORE: 0.7311

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q460K	TCGA-33-AASI	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.0556
p.Q460K	DO219129	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0556
p.L458V	TCGA-75-6207	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1111
p.L458V	DO26190	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1111
p.P439S	TCGA-90-A4ED	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439S	TCGA-D3-A3MU	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439S	TCGA-D3-A8GI	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439S	DO45482	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439S	DO50284	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439S	DO47337	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.L456S	TCGA-AP-A0LM	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1667
p.L456S	DO43306	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1667
p.L455V	TCGA-AX-A2HC	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1944
p.L455V	DO41572	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.P442H	TCGA-D1-A16X	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.2222
p.P442H	DO41799	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.S452F	TCGA-D3-A3C8	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.2778
p.S452F	DO47636	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.L456M	TCGA-EE-A2M5	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1667
p.L456M	DO37425	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1667
p.P446S	TCGA-ER-A2ND	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.6752
p.P446S	DO47449	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.P439L	TCGA-FR-A8YE	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439L	DO50303	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439L	SIDM01175	Other Sarcomas	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439L	ACH-002309	Sarcoma	CCLE	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P439L	SW684	soft_tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.V447G	TCGA-HF-7136	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V447G	DO38226	STAD	ICGC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V447G	SIDM01451	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V447G	SIDM00678	Bladder Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V447G	SIDM00282	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V447G	SIDM00379	Glioma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V447G	SIDM01336	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V447G	HT-1376	urinary_tract	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V447G	CW-2	large_intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.S450C	TCGA-IR-A3LH	CESC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.7541
p.S450C	DO44381	CESC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.7541
p.L458I	TCGA-ND-A4WC	UCS	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1111
p.L458I	DO232445	PBCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1111
p.L458I	SIDM00798	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1111
p.L458I	SIDM01101	Neuroblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1111
p.Y453C	TCGA-OR-A5LB	ACC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.25
p.P446L	TCGA-XE-AAO4	TGCT	TCGA	PVSSS	DEG_SPOP_SBC_1	0.7582
p.P442S	DO229361	BTCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.Y453S	DO229345	LAML	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.Y453S	DO228902	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.Y453S	DO228976	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.Y453S	DO228891	MALY	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.Y453S	NCI-H1105	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.25
p.G437C	DO228942	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.P442L	DO44792	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.F451S	DO46949	RECA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.3056
p.F451S	NCI-H1105	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.3056
p.L456V	SIDM00798	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1667
p.T454I	SIDM00258	Neuroblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.T454I	ACH-002279	Neuroblastoma	CCLE	PVSSS	DEG_SPOP_SBC_1	0.2222
p.T454I	NB12	autonomic_ganglia	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60381	HMG box-containing protein 1	DEG_SPOP_SBC_1	154:158	PVSSS	SPOP	0.9698	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	380:384	PVSSS	SPOP	0.8257	More...
P07196	Neurofilament light polypeptide	DEG_SPOP_SBC_1	46:50	PVSSS	SPOP	0.8899	More...
P19793	Retinoic acid receptor RXR-alpha	DEG_SPOP_SBC_1	100:104	PVSSS	SPOP	0.9322	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	599:603	PVSSS	SPOP	0.9897	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1234:1238	PVSSS	SPOP	0.8806	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	869:873	PVSSS	SPOP	0.7599	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	567:571	PVSSS	SPOP	0.8885	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	590:594	PVSSS	SPOP	0.8983	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1009:1013	PVSSS	SPOP	0.7108	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1582:1586	PVSSS	SPOP	0.9597	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1810:1814	PVSSS	SPOP	0.9944	More...
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SPOP_SBC_1	2893:2897	PVSSS	SPOP	0.9847	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	916:920	PVSSS	SPOP	0.9081	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	631:635	PVSSS	SPOP	0.9929	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	588:592	PVSSS	SPOP	0.6309	More...
Q6ZN04	RNA-binding protein MEX3B	DEG_SPOP_SBC_1	391:395	PVSSS	SPOP	0.9174	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	593:597	PVSSS	SPOP	0.7583	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1237:1241	PVSSS	SPOP	0.926	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	1586:1590	PVSSS	SPOP	0.8722	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	97:101	PVSSS	SPOP	0.8909	More...
Q8NDF8	Terminal nucleotidyltransferase 4B	DEG_SPOP_SBC_1	445:449	PVSSS	SPOP	0.9935	More...
Q8NEY1	Neuron navigator 1	DEG_SPOP_SBC_1	693:697	PVSSS	SPOP	0.9862	More...
Q92613	Protein Jade-3	DEG_SPOP_SBC_1	6:10	PVSSS	SPOP	0.9389	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	891:895	PVSSS	SPOP	0.9523	More...
Q9C0C6	CLOCK-interacting pacemaker	DEG_SPOP_SBC_1	245:249	PVSSS	SPOP	0.9936	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1701:1705	PVSSS	SPOP	0.996	More...
Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	DEG_SPOP_SBC_1	369:373	PVSSS	SPOP	0.8095	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	1122:1126	PVSSS	SPOP	0.992	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	977:981	PVSSS	SPOP	0.9676	More...
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	DEG_SPOP_SBC_1	1245:1249	PVSSS	SPOP	0.9694	More...
A0AUZ9	KAT8 regulatory NSL complex subunit 1-like protein	DEG_SPOP_SBC_1	208:212	PVSSS	SPOP	0.5228	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	306:310	PVSSS	SPOP	0.9847	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	446:450	PVSSS	SPOP	0.94	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	481:485	PVSSS	SPOP	0.9669	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	337:341	PVSSS	SPOP	0.9791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSSS

Degron related mutations and impact score

Drug responses associated with MAGEC1 mutations

All proteins holding degron of PVSSS