TENT4B
UniProt ID: Q8NDF8
Entrez ID: 64282
Protein name: Terminal nucleotidyltransferase 4B (Non-canonical poly(A) RNA polymerase PAPD5) (EC 2.7.7.19) (PAP-associated domain-containing protein 5) (Terminal guanylyltransferase) (EC 2.7.7.-) (Terminal uridylyltransferase 3) (TUTase 3) (Topoisomerase-related function protein 4-2) (TRF4-2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a ca...
FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}.
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GO - Biological processes (BP):
carbohydrate homeostasis [GO:0033500]; cell cycle [GO:0007049]; cell division [GO:0051301]; histone mRNA catabolic process [GO:0071044]; miRNA catabolic process [GO:0010587]; mRNA polyadenylation [GO:0006378]; ncRNA polyadenylation [GO:0043629]; ncRNA polyadenylation involved in polyadenylation-depe...
carbohydrate homeostasis [GO:0033500]; cell cycle [GO:0007049]; cell division [GO:0051301]; histone mRNA catabolic process [GO:0071044]; miRNA catabolic process [GO:0010587]; mRNA polyadenylation [GO:0006378]; ncRNA polyadenylation [GO:0043629]; ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process [GO:0043630]; negative regulation of nuclear-transcribed mRNA poly(A) tail shortening [GO:0060212]; negative regulation of telomere maintenance via telomerase [GO:0032211]; positive regulation of 3'-UTR-mediated mRNA stabilization [GO:1905870]; RNA 3'-end processing [GO:0031123]; RNA 3' uridylation [GO:0071076]; rRNA processing [GO:0006364]; sno(s)RNA polyadenylation [GO:0071050]
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GO - Molecular function (MF):
DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]...
DNA binding [GO:0003677]; DNA-directed DNA polymerase activity [GO:0003887]; guanylyltransferase activity [GO:0070568]; metal ion binding [GO:0046872]; polynucleotide adenylyltransferase activity [GO:0004652]; RNA binding [GO:0003723]; telomerase RNA binding [GO:0070034]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; TRAMP complex [GO:0031499]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; nucleolus [GO:0005730]; plasma membrane [GO:0005886]; TRAMP complex [GO:0031499]
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TENT4B
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*NOTE: the Kaplan plots were collected from OncoLnc