DegronMD

Uniprot ID: Q8NDF8

Source protein: Terminal nucleotidyltransferase 4B

Source gene: TENT4B

Class: DEG_SPOP_SBC_1

Location: 445:449

E3 ligase: SPOP

DEGRON score: 0.9935

ASA_SCORE: 80.38

COIL: 0.9542

CONS_SCORE: 0.202

DSS_SCORE: 0.6504

HELIX: 0.0244

FCONS_SCORE: 0.9878

RIG_SCORE: 0.5634

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T446A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.7139
p.K445N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6918
p.S449P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.N436K	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 4 of 4 entries

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Drug responses associated with TENT4B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PVSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	869:873	PVSSS	SPOP	0.7599	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	567:571	PVSSS	SPOP	0.8885	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	588:592	PVSSS	SPOP	0.6309	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1701:1705	PVSSS	SPOP	0.996	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	380:384	PVSSS	SPOP	0.8257	More...
Q9C0C6	CLOCK-interacting pacemaker	DEG_SPOP_SBC_1	245:249	PVSSS	SPOP	0.9936	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1237:1241	PVSSS	SPOP	0.926	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	891:895	PVSSS	SPOP	0.9523	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	593:597	PVSSS	SPOP	0.7583	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	97:101	PVSSS	SPOP	0.8909	More...
O60381	HMG box-containing protein 1	DEG_SPOP_SBC_1	154:158	PVSSS	SPOP	0.9698	More...
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	DEG_SPOP_SBC_1	1245:1249	PVSSS	SPOP	0.9694	More...
A0AUZ9	KAT8 regulatory NSL complex subunit 1-like protein	DEG_SPOP_SBC_1	208:212	PVSSS	SPOP	0.5228	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	1586:1590	PVSSS	SPOP	0.8722	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	306:310	PVSSS	SPOP	0.9847	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	446:450	PVSSS	SPOP	0.94	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	481:485	PVSSS	SPOP	0.9669	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1009:1013	PVSSS	SPOP	0.7108	More...
P07196	Neurofilament light polypeptide	DEG_SPOP_SBC_1	46:50	PVSSS	SPOP	0.8899	More...
Q8NEY1	Neuron navigator 1	DEG_SPOP_SBC_1	693:697	PVSSS	SPOP	0.9862	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1234:1238	PVSSS	SPOP	0.8806	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	599:603	PVSSS	SPOP	0.9897	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1582:1586	PVSSS	SPOP	0.9597	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1810:1814	PVSSS	SPOP	0.9944	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	337:341	PVSSS	SPOP	0.9791	More...

Showing 1 to 25 of 36 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSSS

Degron related mutations and impact score

Drug responses associated with TENT4B mutations

All proteins holding degron of PVSSS