DegronMD - Q8TDY8(IGDCC4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E155D	TCGA-38-4631	LUAD	TCGA	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.E155D	TCGA-DJ-A2QB	THCA	TCGA	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.E155D	DO24970	LUAD	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.E155D	DO39421	THCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1944
p.Q152H	TCGA-62-A46O	LUAD	TCGA	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.Q152H	DO26240	LUAD	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2778
p.P1211L	TCGA-A5-A0VP	UCEC	TCGA	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.1111
p.P1211L	DO42600	UCEC	ICGC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.1111
p.F145L	TCGA-BA-4077	HNSC	TCGA	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.587
p.F145L	DO15647	HNSC	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.587
p.H1136Y	TCGA-BC-A8YO	LIHC	TCGA	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation altering degron motif	0.6118
p.H1136Y	DO49658	LIHC	ICGC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation altering degron motif	0.6118
p.R980H	TCGA-CV-6940	HNSC	TCGA	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.25
p.R980H	DO15903	HNSC	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.25
p.V154A	TCGA-D8-A1XK	BRCA	TCGA	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.V154A	DO4749	BRCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.V136I	TCGA-DF-A2KU	UCEC	TCGA	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.V136I	DO223286	UCEC	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.E985V	TCGA-E2-A1AZ	BRCA	TCGA	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation altering degron motif	0.6582
p.E985V	DO1727	BRCA	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation altering degron motif	0.6582
p.G1224E	TCGA-EK-A2PI	CESC	TCGA	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation altering degron motif	0.6087
p.G1224E	DO6338	CESC	ICGC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation altering degron motif	0.6087
p.S1244F	TCGA-ER-A194	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	1245:1249	Mutation rewiring degron network	0.3056
p.S1244F	DO47646	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	1245:1249	Mutation rewiring degron network	0.3056
p.R979H	TCGA-FI-A2D5	UCEC	TCGA	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.2222
p.R979H	DO9876	COAD	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.2222
p.R979H	DO233716	GACA	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.2222
p.R979H	DO41331	UCEC	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.2222
p.R979H	SIDM01049	Non-Cancerous	GDSC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.2222
p.R979H	ACH-000038	Lymphoma	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.2222
p.R979H	EHEB	haematopoietic and lymphoid tissue	COSMIC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.2222
p.G1240S	TCGA-FS-A1ZK	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	1245:1249	Mutation rewiring degron network	0.1944
p.G1240S	DO37474	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	1245:1249	Mutation rewiring degron network	0.1944
p.P1234S	TCGA-FW-A3R5	SKCM	TCGA	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.1111
p.P1234S	DO37406	SKCM	ICGC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.1111
p.P1234S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.1111
p.P1234S	ACH-000809	Esophageal Cancer	CCLE	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.1111
p.P1234S	KYSE-410	oesophagus	COSMIC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.1111
p.P1223S	TCGA-L5-A8NS	ESCA	TCGA	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation altering degron motif	0.6752
p.L990P	DO228247	BRCA	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation altering degron motif	0.7582
p.E156D	DO1071	BRCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1667
p.C1125Y	DO229010	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.1111
p.C1125Y	DO229013	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.1111
p.C1125Y	DO229016	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.1111
p.C1125Y	DO229003	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.1111
p.C1125Y	DO229005	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.1111
p.C1125Y	DO229353	LAML	ICGC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.1111
p.L1229F	DO234230	ESAD	ICGC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.25
p.P1242L	DO233240	GACA	ICGC	PVSSS	DEG_SPOP_SBC_1	1245:1249	Mutation rewiring degron network	0.25
p.P1211T	DO229024	LICA	ICGC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.1111
p.A976T	DO23186	LINC	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.1389
p.D1225N	DO46518	OV	ICGC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation altering degron motif	0.5821
p.G989C	DO35083	PACA	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation altering degron motif	0.6489
p.G158R	DO35759	PBCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.1111
p.A1131D	DO232761	PBCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.2778
p.V1218G	DO218900	SKCA	ICGC	LEETPGDS	DEG_SCF_FBW7_1	1219:1226	Mutation rewiring degron network	0.3056
p.T159I	DO229211	THCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0833
p.V154M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.V154M	ACH-000983	Leukemia	CCLE	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.V154M	KCL-22	haematopoietic and lymphoid tissue	COSMIC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.2222
p.A135D	SIDM00120	Prostate Carcinoma	GDSC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0556
p.A135D	ACH-000979	Prostate Cancer	CCLE	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0556
p.A135D	DU-145	prostate	COSMIC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation rewiring degron network	0.0556
p.A1141S	SIDM00417	Plasma Cell Myeloma	GDSC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.25
p.A1141S	ACH-000626	Myeloma	CCLE	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.25
p.A1141S	U-266	haematopoietic and lymphoid tissue	COSMIC	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.25
p.A1000V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.0833
p.A1000V	ACH-001738	Leukemia	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.0833
p.L147V	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.5654
p.L147V	ACH-000705	Lung Cancer	CCLE	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.5654
p.L147V	ACH-001113	Lung Cancer	CCLE	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.5654
p.L147V	ACH-002156	Lung Cancer	CCLE	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.5654
p.L147V	LC-1-sq	lung	COSMIC	FSLHPE	LIG_APCC_ABBA_1	145:150	Mutation altering degron motif	0.5654
p.A994T	SIDM01588	Endometrial Carcinoma	GDSC	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.25
p.A994T	ACH-000993	Endometrial/Uterine Cancer	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.25
p.L987H	ACH-000246	Kidney Cancer	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation altering degron motif	0.7313
p.R980L	ACH-000945	Lung Cancer	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	983:991	Mutation rewiring degron network	0.25
p.F1139S	ACH-000954	Endometrial/Uterine Cancer	CCLE	VIVHSD	LIG_APCC_ABBA_1	1133:1138	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IGDCC4

UniProt ID: Q8TDY8

Entrez ID: 57722

Protein name: Immunoglobulin superfamily DCC subclass member 4 (Neighbor of punc e11) (Protein DDM36) (hDDM36)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IGDCC4 in