DegronMD

Uniprot ID: Q8TDY8

Source protein: Immunoglobulin superfamily DCC subclass member 4

Source gene: IGDCC4

Class: DEG_SCF_FBW7_1

Location: 1219:1226

E3 ligase: FBXW7

DEGRON score: 0.6405

ASA_SCORE: 84.5

COIL: 0.9015

CONS_SCORE: 0.3329

DSS_SCORE: 0.5556

HELIX: 0.0406

FCONS_SCORE: 0.9295

RIG_SCORE: 0.6826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1211L	TCGA-A5-A0VP	UCEC	TCGA	LEETPGDS	DEG_SCF_FBW7_1	0.1111
p.P1211L	DO42600	UCEC	ICGC	LEETPGDS	DEG_SCF_FBW7_1	0.1111
p.G1224E	TCGA-EK-A2PI	CESC	TCGA	LEETPGDS	DEG_SCF_FBW7_1	0.6087
p.G1224E	DO6338	CESC	ICGC	LEETPGDS	DEG_SCF_FBW7_1	0.6087
p.P1234S	TCGA-FW-A3R5	SKCM	TCGA	LEETPGDS	DEG_SCF_FBW7_1	0.1111
p.P1234S	DO37406	SKCM	ICGC	LEETPGDS	DEG_SCF_FBW7_1	0.1111
p.P1234S	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	LEETPGDS	DEG_SCF_FBW7_1	0.1111
p.P1234S	ACH-000809	Esophageal Cancer	CCLE	LEETPGDS	DEG_SCF_FBW7_1	0.1111
p.P1234S	KYSE-410	oesophagus	COSMIC	LEETPGDS	DEG_SCF_FBW7_1	0.1111
p.P1223S	TCGA-L5-A8NS	ESCA	TCGA	LEETPGDS	DEG_SCF_FBW7_1	0.6752
p.L1229F	DO234230	ESAD	ICGC	LEETPGDS	DEG_SCF_FBW7_1	0.25
p.P1211T	DO229024	LICA	ICGC	LEETPGDS	DEG_SCF_FBW7_1	0.1111
p.D1225N	DO46518	OV	ICGC	LEETPGDS	DEG_SCF_FBW7_1	0.5821
p.V1218G	DO218900	SKCA	ICGC	LEETPGDS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	DEG_SCF_FBW7_1	1219:1226	LEETPGDS	FBXW7	0.6405	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons