DegronMD

Uniprot ID: Q8TDY8

Source protein: Immunoglobulin superfamily DCC subclass member 4

Source gene: IGDCC4

Class: LIG_APCC_ABBA_1

Location: 1133:1138

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8757

ASA_SCORE: 51.9333

COIL: 0.357

CONS_SCORE: 0.9223

DSS_SCORE: 0.49

HELIX: 0.0347

FCONS_SCORE: 1.4724

RIG_SCORE: 0.7679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1136Y	TCGA-BC-A8YO	LIHC	TCGA	VIVHSD	LIG_APCC_ABBA_1	0.6118
p.H1136Y	DO49658	LIHC	ICGC	VIVHSD	LIG_APCC_ABBA_1	0.6118
p.C1125Y	DO229010	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	0.1111
p.C1125Y	DO229013	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	0.1111
p.C1125Y	DO229016	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	0.1111
p.C1125Y	DO229003	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	0.1111
p.C1125Y	DO229005	COCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	0.1111
p.C1125Y	DO229353	LAML	ICGC	VIVHSD	LIG_APCC_ABBA_1	0.1111
p.A1131D	DO232761	PBCA	ICGC	VIVHSD	LIG_APCC_ABBA_1	0.2778
p.A1141S	SIDM00417	Plasma Cell Myeloma	GDSC	VIVHSD	LIG_APCC_ABBA_1	0.25
p.A1141S	ACH-000626	Myeloma	CCLE	VIVHSD	LIG_APCC_ABBA_1	0.25
p.A1141S	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	VIVHSD	LIG_APCC_ABBA_1	0.25
p.F1139S	ACH-000954	Endometrial/Uterine Cancer	CCLE	VIVHSD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	LIG_APCC_ABBA_1	1133:1138	VIVHSD	APC,CDC20,FZR1	0.8757	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons