DegronMD

Uniprot ID: Q8TDY8

Source protein: Immunoglobulin superfamily DCC subclass member 4

Source gene: IGDCC4

Class: LIG_APCC_ABBA_1

Location: 145:150

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5985

ASA_SCORE: 79.0333

COIL: 0.6167

CONS_SCORE: 0.7836

DSS_SCORE: 0.3142

HELIX: 0.0047

FCONS_SCORE: 1.0689

RIG_SCORE: 0.7608

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E155D	TCGA-38-4631	LUAD	TCGA	FSLHPE	LIG_APCC_ABBA_1	0.1944
p.E155D	TCGA-DJ-A2QB	THCA	TCGA	FSLHPE	LIG_APCC_ABBA_1	0.1944
p.E155D	DO24970	LUAD	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.1944
p.E155D	DO39421	THCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.1944
p.Q152H	TCGA-62-A46O	LUAD	TCGA	FSLHPE	LIG_APCC_ABBA_1	0.2778
p.Q152H	DO26240	LUAD	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.2778
p.F145L	TCGA-BA-4077	HNSC	TCGA	FSLHPE	LIG_APCC_ABBA_1	0.587
p.F145L	DO15647	HNSC	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.587
p.V154A	TCGA-D8-A1XK	BRCA	TCGA	FSLHPE	LIG_APCC_ABBA_1	0.2222
p.V154A	DO4749	BRCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.2222
p.V136I	TCGA-DF-A2KU	UCEC	TCGA	FSLHPE	LIG_APCC_ABBA_1	0.0833
p.V136I	DO223286	UCEC	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.0833
p.E156D	DO1071	BRCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.1667
p.G158R	DO35759	PBCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.1111
p.T159I	DO229211	THCA	ICGC	FSLHPE	LIG_APCC_ABBA_1	0.0833
p.V154M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	FSLHPE	LIG_APCC_ABBA_1	0.2222
p.V154M	ACH-000983	Leukemia	CCLE	FSLHPE	LIG_APCC_ABBA_1	0.2222
p.V154M	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	FSLHPE	LIG_APCC_ABBA_1	0.2222
p.A135D	SIDM00120	Prostate Carcinoma	GDSC	FSLHPE	LIG_APCC_ABBA_1	0.0556
p.A135D	ACH-000979	Prostate Cancer	CCLE	FSLHPE	LIG_APCC_ABBA_1	0.0556
p.A135D	DU-145	prostate	COSMIC	FSLHPE	LIG_APCC_ABBA_1	0.0556
p.L147V	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	FSLHPE	LIG_APCC_ABBA_1	0.5654
p.L147V	ACH-000705	Lung Cancer	CCLE	FSLHPE	LIG_APCC_ABBA_1	0.5654
p.L147V	ACH-001113	Lung Cancer	CCLE	FSLHPE	LIG_APCC_ABBA_1	0.5654
p.L147V	ACH-002156	Lung Cancer	CCLE	FSLHPE	LIG_APCC_ABBA_1	0.5654
p.L147V	LC-1-sq	lung	COSMIC	FSLHPE	LIG_APCC_ABBA_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	LIG_APCC_ABBA_1	145:150	FSLHPE	APC,CDC20,FZR1	0.5985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FSLHPE

Degron related mutations and impact score

Drug responses associated with IGDCC4 mutations

All proteins holding degron of FSLHPE