DegronMD

Uniprot ID: Q8TDY8

Source protein: Immunoglobulin superfamily DCC subclass member 4

Source gene: IGDCC4

Class: DEG_APCC_DBOX_1

Location: 983:991

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9479

ASA_SCORE: 97.8667

COIL: 0.897

CONS_SCORE: 0.699

DSS_SCORE: 0.4817

HELIX: 0.0739

FCONS_SCORE: 1.0613

RIG_SCORE: 0.6568

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R980H	TCGA-CV-6940	HNSC	TCGA	HRESLPGLS	DEG_APCC_DBOX_1	0.25
p.R980H	DO15903	HNSC	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	0.25
p.E985V	TCGA-E2-A1AZ	BRCA	TCGA	HRESLPGLS	DEG_APCC_DBOX_1	0.6582
p.E985V	DO1727	BRCA	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	0.6582
p.R979H	TCGA-FI-A2D5	UCEC	TCGA	HRESLPGLS	DEG_APCC_DBOX_1	0.2222
p.R979H	DO9876	COAD	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	0.2222
p.R979H	DO233716	GACA	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	0.2222
p.R979H	DO41331	UCEC	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	0.2222
p.R979H	SIDM01049	Non-Cancerous	GDSC	HRESLPGLS	DEG_APCC_DBOX_1	0.2222
p.R979H	ACH-000038	Lymphoma	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	0.2222
p.R979H	EHEB	haematopoietic_and_lymphoid_tissue	COSMIC	HRESLPGLS	DEG_APCC_DBOX_1	0.2222
p.L990P	DO228247	BRCA	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	0.7582
p.A976T	DO23186	LINC	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	0.1389
p.G989C	DO35083	PACA	ICGC	HRESLPGLS	DEG_APCC_DBOX_1	0.6489
p.A1000V	SIDM00121	T-Lymphoblastic Leukemia	GDSC	HRESLPGLS	DEG_APCC_DBOX_1	0.0833
p.A1000V	ACH-001738	Leukemia	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	0.0833
p.A994T	SIDM01588	Endometrial Carcinoma	GDSC	HRESLPGLS	DEG_APCC_DBOX_1	0.25
p.A994T	ACH-000993	Endometrial/Uterine Cancer	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	0.25
p.L987H	ACH-000246	Kidney Cancer	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	0.7313
p.R980L	ACH-000945	Lung Cancer	CCLE	HRESLPGLS	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	DEG_APCC_DBOX_1	983:991	HRESLPGLS	APC,CDC20,FZR1	0.9479	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons