DegronMD - Q9C0C6(CIPC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A164V	TCGA-A5-A1OF	UCEC	TCGA	IAPHPGKRGLSL	DEG_ODPH_VHL_1	163:174	Mutation altering degron motif	0.6936
p.G387D	TCGA-AB-2808	LAML	TCGA	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation rewiring degron network	0.25
p.L379F	TCGA-AD-6895	COAD	TCGA	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.6981
p.L379F	TCGA-GF-A6C9	SKCM	TCGA	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.6981
p.R151S	TCGA-AJ-A23O	UCEC	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.7427
p.R170M	TCGA-AX-A1CE	UCEC	TCGA	IAPHPGKRGLSL	DEG_ODPH_VHL_1	163:174	Mutation altering degron motif	0.7521
p.R170M	TCGA-DF-A2KU	UCEC	TCGA	IAPHPGKRGLSL	DEG_ODPH_VHL_1	163:174	Mutation altering degron motif	0.7521
p.D149N	TCGA-AX-A2HC	UCEC	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.3056
p.S150F	TCGA-B5-A1MX	UCEC	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	150:158	Mutation altering degron motif	0.6871
p.E145K	TCGA-BH-A2L8	BRCA	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.1944
p.G144C	TCGA-D3-A2JP	SKCM	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.1667
p.S148F	TCGA-D3-A8GM	SKCM	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.2778
p.P140L	TCGA-WE-A8K6	SKCM	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	150:158	Mutation rewiring degron network	0.0556
p.G382W	SIDM01095	Rhabdomyosarcoma	GDSC	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.6714
p.G382W	SJRH30	soft tissue	COSMIC	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.6714
p.P381R	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.7512
p.P381R	BC-3	haematopoietic and lymphoid tissue	COSMIC	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.7512
p.T380I	SIDM00801	Melanoma	GDSC	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.7078
p.T380I	A101D	skin	COSMIC	LTPGSS	DEG_SCF_FBW7_1	379:384	Mutation altering degron motif	0.7078
p.P240Q	SIDM00115	Head and Neck Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.P240Q	PCI-6A	upper aerodigestive tract	COSMIC	PVSSS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944

Kaplan plot for CIPC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CIPC

UniProt ID: Q9C0C6

Entrez ID: 85457

Protein name: CLOCK-interacting pacemaker (CLOCK-interacting circadian protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CIPC in