DegronMD

Uniprot ID: Q9C0C6

Source protein: CLOCK-interacting pacemaker

Source gene: CIPC

Class: DEG_SCF_FBW7_1

Location: 379:384

E3 ligase: FBXW7

DEGRON score: 0.9008

ASA_SCORE: 67.9167

COIL: 0.8613

CONS_SCORE: 0.5207

DSS_SCORE: 0.4688

HELIX: 0.1065

FCONS_SCORE: 0.8013

RIG_SCORE: 0.6

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G387D	TCGA-AB-2808	LAML	TCGA	LTPGSS	DEG_SCF_FBW7_1	0.25
p.L379F	TCGA-AD-6895	COAD	TCGA	LTPGSS	DEG_SCF_FBW7_1	0.6981
p.L379F	TCGA-GF-A6C9	SKCM	TCGA	LTPGSS	DEG_SCF_FBW7_1	0.6981
p.G382W	SIDM01095	Rhabdomyosarcoma	GDSC	LTPGSS	DEG_SCF_FBW7_1	0.6714
p.G382W	SJRH30	soft_tissue	COSMIC	LTPGSS	DEG_SCF_FBW7_1	0.6714
p.P381R	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPGSS	DEG_SCF_FBW7_1	0.7512
p.P381R	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	LTPGSS	DEG_SCF_FBW7_1	0.7512
p.T380I	SIDM00801	Melanoma	GDSC	LTPGSS	DEG_SCF_FBW7_1	0.7078
p.T380I	A101D	skin	COSMIC	LTPGSS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C6	CLOCK-interacting pacemaker	DEG_SCF_FBW7_1	379:384	LTPGSS	FBXW7	0.9008	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons