DegronMD

Uniprot ID: Q9C0C6

Source protein: CLOCK-interacting pacemaker

Source gene: CIPC

Class: DEG_APCC_DBOX_1

Location: 150:158

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9225

ASA_SCORE: 70.3667

COIL: 0.7756

CONS_SCORE: 0.7018

DSS_SCORE: 0.5141

HELIX: 0.1186

FCONS_SCORE: 0.9951

RIG_SCORE: 0.7487

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R151S	TCGA-AJ-A23O	UCEC	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	0.7427
p.D149N	TCGA-AX-A2HC	UCEC	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	0.3056
p.S150F	TCGA-B5-A1MX	UCEC	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	0.6871
p.E145K	TCGA-BH-A2L8	BRCA	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	0.1944
p.G144C	TCGA-D3-A2JP	SKCM	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	0.1667
p.S148F	TCGA-D3-A8GM	SKCM	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	0.2778
p.P140L	TCGA-WE-A8K6	SKCM	TCGA	SRNYLPILN	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0C6	CLOCK-interacting pacemaker	DEG_APCC_DBOX_1	150:158	SRNYLPILN	APC,CDC20,FZR1	0.9225	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons