DegronMD

Uniprot ID: O60732

Source protein: Melanoma-associated antigen C1

Source gene: MAGEC1

Class: DEG_SPOP_SBC_1

Location: 306:310

E3 ligase: SPOP

DEGRON score: 0.9847

ASA_SCORE: 85.68

COIL: 0.9702

CONS_SCORE: 0.4048

DSS_SCORE: 0.3953

HELIX: 0.0128

FCONS_SCORE: 0.9917

RIG_SCORE: 0.6524

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E296D	TCGA-17-Z003	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	0.0556
p.E296V	TCGA-78-7536	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	0.0556
p.E296V	DO26414	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0556
p.S301Y	TCGA-AA-A03F	COAD	TCGA	PVSSS	DEG_SPOP_SBC_1	0.6389
p.S301Y	DO10558	COAD	ICGC	PVSSS	DEG_SPOP_SBC_1	0.6389
p.Q304K	TCGA-ER-A2NB	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.2778
p.Q304K	DO47448	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.P306H	TCGA-F5-6814	READ	TCGA	PVSSS	DEG_SPOP_SBC_1	0.7694
p.P306H	DO36556	READ	ICGC	PVSSS	DEG_SPOP_SBC_1	0.7694
p.S313F	TCGA-FS-A1Z3	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.25
p.S313F	TCGA-QQ-A5VD	SARC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.25
p.S313F	DO220252	SARC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.S313F	DO37635	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.Q300K	TCGA-V5-A7RC	ESCA	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1667
p.V307M	DO4138	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01518	Oral Cavity Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01137	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01722	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00174	Head and Neck Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01090	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00602	Gastric Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00697	Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00795	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00908	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00180	Kidney Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00505	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01063	Acute Myeloid Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00968	Ovarian Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00629	Breast Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00685	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01645	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00380	Acute Myeloid Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00196	Ewing's Sarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01205	Acute Myeloid Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00123	Kidney Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM00303	Ovarian Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.V307M	SIDM01761	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6097
p.S309P	DO224685	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.7863
p.S309P	DO222774	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.7863
p.S309P	DO229232	THCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.7863
p.P302S	DO222741	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.P299A	DO222741	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P299A	DO218872	SKCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.S312F	DO233663	GACA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.P302L	DO229029	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.P299S	DO222363	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P299S	MEL-HO	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.S311F	DO35558	PBCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.3056
p.S313Y	SIDM01295	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.25
p.P299L	SIDM00545	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P299L	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P299L	ACH-000875	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P299L	ACH-000987	Skin Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P299L	NCI-H2347	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P299L	Mewo	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.L303P	SIDM00222	Mesothelioma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.25
p.L303P	ACH-000319	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	0.25
p.L303P	MPP-89	pleura	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.25
p.S301C	SIDM00710	Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6389
p.S301C	ACH-000394	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	0.6389
p.S301C	NCI-H2081	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6389
p.L315S	SIDM00208	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.L315S	ACH-002229	Brain Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	0.1944
p.L315S	D-502MG	central_nervous_system	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.S310F	Mewo	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.7982
p.V307G	KYSE-140	oesophagus	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V307G	LU-139	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60381	HMG box-containing protein 1	DEG_SPOP_SBC_1	154:158	PVSSS	SPOP	0.9698	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	380:384	PVSSS	SPOP	0.8257	More...
P07196	Neurofilament light polypeptide	DEG_SPOP_SBC_1	46:50	PVSSS	SPOP	0.8899	More...
P19793	Retinoic acid receptor RXR-alpha	DEG_SPOP_SBC_1	100:104	PVSSS	SPOP	0.9322	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	599:603	PVSSS	SPOP	0.9897	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1234:1238	PVSSS	SPOP	0.8806	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	869:873	PVSSS	SPOP	0.7599	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	567:571	PVSSS	SPOP	0.8885	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	590:594	PVSSS	SPOP	0.8983	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1009:1013	PVSSS	SPOP	0.7108	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1582:1586	PVSSS	SPOP	0.9597	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1810:1814	PVSSS	SPOP	0.9944	More...
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SPOP_SBC_1	2893:2897	PVSSS	SPOP	0.9847	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	916:920	PVSSS	SPOP	0.9081	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	631:635	PVSSS	SPOP	0.9929	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	588:592	PVSSS	SPOP	0.6309	More...
Q6ZN04	RNA-binding protein MEX3B	DEG_SPOP_SBC_1	391:395	PVSSS	SPOP	0.9174	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	593:597	PVSSS	SPOP	0.7583	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1237:1241	PVSSS	SPOP	0.926	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	1586:1590	PVSSS	SPOP	0.8722	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	97:101	PVSSS	SPOP	0.8909	More...
Q8NDF8	Terminal nucleotidyltransferase 4B	DEG_SPOP_SBC_1	445:449	PVSSS	SPOP	0.9935	More...
Q8NEY1	Neuron navigator 1	DEG_SPOP_SBC_1	693:697	PVSSS	SPOP	0.9862	More...
Q92613	Protein Jade-3	DEG_SPOP_SBC_1	6:10	PVSSS	SPOP	0.9389	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	891:895	PVSSS	SPOP	0.9523	More...
Q9C0C6	CLOCK-interacting pacemaker	DEG_SPOP_SBC_1	245:249	PVSSS	SPOP	0.9936	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1701:1705	PVSSS	SPOP	0.996	More...
Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	DEG_SPOP_SBC_1	369:373	PVSSS	SPOP	0.8095	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	1122:1126	PVSSS	SPOP	0.992	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	977:981	PVSSS	SPOP	0.9676	More...
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	DEG_SPOP_SBC_1	1245:1249	PVSSS	SPOP	0.9694	More...
A0AUZ9	KAT8 regulatory NSL complex subunit 1-like protein	DEG_SPOP_SBC_1	208:212	PVSSS	SPOP	0.5228	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	306:310	PVSSS	SPOP	0.9847	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	446:450	PVSSS	SPOP	0.94	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	481:485	PVSSS	SPOP	0.9669	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	337:341	PVSSS	SPOP	0.9791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSSS

Degron related mutations and impact score

Drug responses associated with MAGEC1 mutations

All proteins holding degron of PVSSS