DegronMD - Q15772(SPEG)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P2815L	TCGA-06-5416	GBM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.6471
p.P2815L	TCGA-D3-A2J8	SKCM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.6471
p.P2815L	DO10880	GBM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.6471
p.P2815L	DO37778	SKCM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.6471
p.R1947G	TCGA-17-Z031	LUAD	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation altering degron motif	0.7568
p.P363H	TCGA-49-6761	LUAD	TCGA	PQTPLSE	DEG_SCF_FBW7_2	373:379	Mutation rewiring degron network	0.0556
p.R372L	TCGA-66-2783	LUSC	TCGA	PQTPLSE	DEG_SCF_FBW7_2	373:379	Mutation rewiring degron network	0.3056
p.R639C	TCGA-A6-2686	COAD	TCGA	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.25
p.L2803V	TCGA-AJ-A3EK	UCEC	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.2222
p.L2803V	DO41584	UCEC	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.2222
p.A1959V	TCGA-AP-A1DV	UCEC	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.1944
p.A1959V	DO43186	UCEC	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.1944
p.E1956D	TCGA-BQ-7053	KIRP	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.2778
p.E1956D	DO20946	KIRP	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.2778
p.P2800S	TCGA-CR-7368	HNSC	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1389
p.P2800S	DO14167	HNSC	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1389
p.L2807R	TCGA-D3-A2JL	SKCM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.8428
p.L2807R	DO47278	SKCM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.8428
p.S176F	TCGA-D3-A5GN	SKCM	TCGA	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.7982
p.R1937S	TCGA-D9-A148	SKCM	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0833
p.R1937S	DO37971	SKCM	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0833
p.P2814T	TCGA-DM-A1DA	COAD	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.5919
p.P2814T	DO7852	COAD	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.5919
p.P1936L	TCGA-DT-5265	READ	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0556
p.P1936L	DO36499	READ	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0556
p.P2888S	TCGA-EE-A29L	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1944
p.P2888S	TCGA-FS-A1ZZ	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1944
p.P2888S	TCGA-W3-AA1R	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1944
p.P2888S	DO37835	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1944
p.P2888S	DO37412	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1944
p.P2888S	DO51275	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1944
p.G2890R	TCGA-EE-A2GB	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.25
p.G2890R	DO222683	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.25
p.G2890R	DO37417	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.25
p.P2824S	TCGA-EE-A2MQ	SKCM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1944
p.P2824S	DO37810	SKCM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1944
p.P2824S	SIDM01161	Other Sarcomas	GDSC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1944
p.P2824S	ACH-001274	Sarcoma	CCLE	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1944
p.P2824S	SW982	soft tissue	COSMIC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1944
p.G2770S	TCGA-EE-A2MR	SKCM	TCGA	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.3056
p.G2770S	DO37819	SKCM	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.3056
p.G2770D	TCGA-EE-A2MR	SKCM	TCGA	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.3056
p.G2770D	DO37819	SKCM	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.3056
p.S2822L	TCGA-ER-A193	SKCM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.25
p.S2822L	DO47368	SKCM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.25
p.R1937H	TCGA-EY-A1GI	UCEC	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0833
p.R1937H	DO41211	UCEC	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0833
p.R1937H	SIDM00238	Ovarian Carcinoma	GDSC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0833
p.R1937H	ACH-000947	Ovarian Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0833
p.R1937H	OVK-18	ovary	COSMIC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0833
p.P2812T	TCGA-F7-A61W	HNSC	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.5919
p.P2812T	DO44434	HNSC	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.5919
p.L365M	TCGA-G2-A2EJ	BLCA	TCGA	PQTPLSE	DEG_SCF_FBW7_2	373:379	Mutation rewiring degron network	0.1111
p.A369T	TCGA-HU-A4GF	STAD	TCGA	PQTPLSE	DEG_SCF_FBW7_2	373:379	Mutation rewiring degron network	0.2222
p.V2894G	TCGA-HU-A4GN	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation altering degron motif	0.6421
p.V2894G	DO47833	STAD	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation altering degron motif	0.6421
p.P2827L	TCGA-L9-A444	LUAD	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1111
p.P2827L	DO26015	LUAD	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.1111
p.T2898A	TCGA-OR-A5L2	ACC	TCGA	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.3056
p.E182K	TCGA-RD-A7C1	STAD	TCGA	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1667
p.S165C	DO602	BLCA	ICGC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1944
p.P1936R	DO225319	BRCA	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.0556
p.R2470C	DO44096	COAD	ICGC	DSGGAS	DEG_SCF_TRCP1_1	2476:2481	Mutation rewiring degron network	0.1667
p.R535C	DO7828	COAD	ICGC	PSTPKTS	DEG_SCF_FBW7_1	539:545	Mutation rewiring degron network	0.2222
p.R535C	DO228581	GACA	ICGC	PSTPKTS	DEG_SCF_FBW7_1	539:545	Mutation rewiring degron network	0.2222
p.V2787I	DO227987	COCA	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.1389
p.R442W	DO227988	COCA	ICGC	PWGTPGAS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.2222
p.T1962S	DO222755	COCA	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.1111
p.R2790G	DO229013	COCA	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.0556
p.R2790G	DO229480	LAML	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.0556
p.R2790G	DO229505	LAML	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.0556
p.R2790G	DO230550	LUSC	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.0556
p.R2790G	DO231022	LUSC	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.0556
p.R2790G	DO231102	LUSC	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.0556
p.S2820R	DO227410	EOPC	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.3056
p.A547T	DO50314	ESAD	ICGC	PSTPKTS	DEG_SCF_FBW7_1	539:545	Mutation rewiring degron network	0.2778
p.A547T	DO232761	PBCA	ICGC	PSTPKTS	DEG_SCF_FBW7_1	539:545	Mutation rewiring degron network	0.2778
p.E170Q	DO14862	HNSC	ICGC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.6744
p.G655V	DO228971	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.1667
p.W651C	DO229019	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.2778
p.A643S	DO229022	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.7588
p.A633S	DO229027	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.0833
p.V2907L	DO229031	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0556
p.V2766F	DO229037	LICA	ICGC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation rewiring degron network	0.1944
p.D654Y	DO229045	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.1944
p.A531P	DO50970	LICA	ICGC	PSTPKTS	DEG_SCF_FBW7_1	539:545	Mutation rewiring degron network	0.1111
p.V2907E	DO23130	LINC	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0556
p.A2480V	DO228338	MALY	ICGC	DSGGAS	DEG_SCF_TRCP1_1	2476:2481	Mutation altering degron motif	0.5825
p.A2810V	DO228891	MALY	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.5825
p.G1961E	DO220898	MELA	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.1389
p.L186V	DO35254	PACA	ICGC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.0556
p.P2888L	DO229459	SKCA	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1944
p.H167Y	DO229453	SKCA	ICGC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.25
p.S436F	DO37659	SKCM	ICGC	PWGTPGAS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.0556
p.P645T	DO37643	SKCM	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.7031
p.G632E	DO48665	SKCM	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.0556
p.S455G	DO229264	THCA	ICGC	PWGTPGAS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.2778
p.N644Y	DO229213	THCA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.7059
p.A540T	DO229213	THCA	ICGC	PSTPKTS	DEG_SCF_FBW7_1	539:545	Mutation altering degron motif	0.7139
p.P2899H	DO231286	THCA	ICGC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.2778
p.P646Q	DO39552	THCA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.7035
p.R162W	DO43041	UCEC	ICGC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1111
p.R659H	DO43186	UCEC	ICGC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation substituting flanking lysine	0.1667
p.W643C	SIDM01156	Small Cell Lung Carcinoma	GDSC	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.5889
p.W643C	ACH-000890	Lung Cancer	CCLE	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.5889
p.P2884L	SIDM00672	Hepatocellular Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM01265	Plasma Cell Myeloma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM00773	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM00203	Ewing's Sarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM00032	Bladder Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM00793	Burkitt's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM00224	Mesothelioma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.P2884L	SIDM01318	Hepatocellular Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.0833
p.S2905F	SIDM00857	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1111
p.S2905F	ACH-000572	Skin Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1111
p.S2905F	G-361	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.1111
p.Q2772E	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	TQDSSAVPSA	DEG_COP1_1	2771:2780	Mutation altering degron motif	0.5633
p.P2899S	SIDM00845	Burkitt's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.2778
p.P2899S	SIDM01099	Neuroblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.2778
p.P2899S	SIDM00493	Other Solid Cancers	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.2778
p.P2899S	SIDM01147	Gastric Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation rewiring degron network	0.2778
p.A2804T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation rewiring degron network	0.25
p.T1955N	SIDM00789	Colorectal Carcinoma	GDSC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.3056
p.T1955N	ACH-000997	Colon/Colorectal Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.3056
p.T1955N	ACH-001061	Colon/Colorectal Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.3056
p.T1955N	ACH-001091	Colon/Colorectal Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.3056
p.T1955N	HCT-15	large intestine	COSMIC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.3056
p.S441L	SIDM00007	Other Solid Cancers	GDSC	PWGTPGAS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1944
p.S441L	ACH-001550	Skin Cancer	CCLE	PWGTPGAS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1944
p.D1957E	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.25
p.D1957E	ACH-001233	Lung Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.25
p.D1957E	VMRC-LCD	lung	COSMIC	SRVSLTDIP	DEG_APCC_DBOX_1	1946:1954	Mutation rewiring degron network	0.25
p.V177M	SIDM00210	Ovarian Carcinoma	GDSC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.3056
p.V177M	ACH-000657	Ovarian Cancer	CCLE	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.3056
p.V177M	A2780	ovary	COSMIC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.3056
p.P373L	SIDM00247	Gastric Carcinoma	GDSC	PQTPLSE	DEG_SCF_FBW7_2	373:379	Mutation altering degron motif	0.6471
p.P373L	ACH-000356	Gastric Cancer	CCLE	PQTPLSE	DEG_SCF_FBW7_2	373:379	Mutation altering degron motif	0.6471
p.P373L	MKN45	stomach	COSMIC	PQTPLSE	DEG_SCF_FBW7_2	373:379	Mutation altering degron motif	0.6471
p.S2897C	SIDM01587	Bladder Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation altering degron motif	0.7541
p.S2897C	ACH-000753	Bladder Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	2893:2897	Mutation altering degron motif	0.7541
p.P439R	ACH-000341	Neuroblastoma	CCLE	PWGTPGAS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1389
p.A651S	ACH-000878	Lung Cancer	CCLE	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation rewiring degron network	0.2778
p.Q438R	ACH-000883	Brain Cancer	CCLE	PWGTPGAS	DEG_SCF_FBW7_1	446:453	Mutation rewiring degron network	0.1111
p.Q554K	ACH-000975	Lung Cancer	CCLE	PSTPKTS	DEG_SCF_FBW7_1	539:545	Mutation rewiring degron network	0.0833
p.R2470S	ACH-001484	Leukemia	CCLE	DSGGAS	DEG_SCF_TRCP1_1	2476:2481	Mutation rewiring degron network	0.1667
p.R2470S	ACH-001485	Leukemia	CCLE	DSGGAS	DEG_SCF_TRCP1_1	2476:2481	Mutation rewiring degron network	0.1667
p.A369V	ACH-001518	Endometrial/Uterine Cancer	CCLE	PQTPLSE	DEG_SCF_FBW7_2	373:379	Mutation rewiring degron network	0.2222
p.T645M	ACH-001518	Endometrial/Uterine Cancer	CCLE	PWATPGLE	DEG_SCF_FBW7_2	642:649	Mutation altering degron motif	0.7423
p.P2809S	ACH-002508	Skin Cancer	CCLE	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.6752
p.D184E	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1111
p.D184E	NCI-H2110	lung	COSMIC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation rewiring degron network	0.1111
p.T2813P	JSC-1	haematopoietic and lymphoid tissue	COSMIC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.5919
p.T2813P	EM-2	haematopoietic and lymphoid tissue	COSMIC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	2807:2819	Mutation altering degron motif	0.5919
p.L175S	NCI-H1793	lung	COSMIC	LDTPPTS	DEG_SCF_FBW7_1	170:176	Mutation altering degron motif	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPEG

UniProt ID: Q15772

Entrez ID: 10290

Protein name: Striated muscle preferentially expressed protein kinase (EC 2.7.11.1) (Aortic preferentially expressed protein 1) (APEG-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPEG in