DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_ODPH_VHL_1

Location: 2807:2819

E3 ligase: VHL

DEGRON score: 0.9645

ASA_SCORE: 80.9154

COIL: 0.9237

CONS_SCORE: 0.399

DSS_SCORE: 0.6781

HELIX: 0.023

FCONS_SCORE: 0.8263

RIG_SCORE: 0.5374

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2815L	TCGA-06-5416	GBM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.6471
p.P2815L	TCGA-D3-A2J8	SKCM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.6471
p.P2815L	DO10880	GBM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.6471
p.P2815L	DO37778	SKCM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.6471
p.L2803V	TCGA-AJ-A3EK	UCEC	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.2222
p.L2803V	DO41584	UCEC	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.2222
p.P2800S	TCGA-CR-7368	HNSC	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1389
p.P2800S	DO14167	HNSC	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1389
p.L2807R	TCGA-D3-A2JL	SKCM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.8428
p.L2807R	DO47278	SKCM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.8428
p.P2814T	TCGA-DM-A1DA	COAD	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.5919
p.P2814T	DO7852	COAD	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.5919
p.P2824S	TCGA-EE-A2MQ	SKCM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1944
p.P2824S	DO37810	SKCM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1944
p.P2824S	SIDM01161	Other Sarcomas	GDSC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1944
p.P2824S	ACH-001274	Sarcoma	CCLE	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1944
p.P2824S	SW982	soft_tissue	COSMIC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1944
p.S2822L	TCGA-ER-A193	SKCM	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.25
p.S2822L	DO47368	SKCM	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.25
p.P2812T	TCGA-F7-A61W	HNSC	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.5919
p.P2812T	DO44434	HNSC	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.5919
p.P2827L	TCGA-L9-A444	LUAD	TCGA	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1111
p.P2827L	DO26015	LUAD	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.1111
p.S2820R	DO227410	EOPC	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.3056
p.A2810V	DO228891	MALY	ICGC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.5825
p.A2804T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.25
p.P2809S	ACH-002508	Skin Cancer	CCLE	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.6752
p.T2813P	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.5919
p.T2813P	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	LAPAAPTPPSVTV	DEG_ODPH_VHL_1	0.5919

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPAAPTPPSVTV

Degron related mutations and impact score

Drug responses associated with SPEG mutations

All proteins holding degron of LAPAAPTPPSVTV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_ODPH_VHL_1	2807:2819	LAPAAPTPPSVTV	VHL	0.9645	More...