DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_SCF_FBW7_1

Location: 539:545

E3 ligase: FBXW7

DEGRON score: 0.8123

ASA_SCORE: 90.0714

COIL: 0.8886

CONS_SCORE: 0.562

DSS_SCORE: 0.7568

HELIX: 0.0303

FCONS_SCORE: 1.0591

RIG_SCORE: 0.5471

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R535C	DO7828	COAD	ICGC	PSTPKTS	DEG_SCF_FBW7_1	0.2222
p.R535C	DO228581	GACA	ICGC	PSTPKTS	DEG_SCF_FBW7_1	0.2222
p.A547T	DO50314	ESAD	ICGC	PSTPKTS	DEG_SCF_FBW7_1	0.2778
p.A547T	DO232761	PBCA	ICGC	PSTPKTS	DEG_SCF_FBW7_1	0.2778
p.A531P	DO50970	LICA	ICGC	PSTPKTS	DEG_SCF_FBW7_1	0.1111
p.A540T	DO229213	THCA	ICGC	PSTPKTS	DEG_SCF_FBW7_1	0.7139
p.Q554K	ACH-000975	Lung Cancer	CCLE	PSTPKTS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SCF_FBW7_1	539:545	PSTPKTS	FBXW7	0.8123	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons