DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_SCF_FBW7_2

Location: 373:379

E3 ligase: FBXW7

DEGRON score: 0.9962

ASA_SCORE: 85.4143

COIL: 0.6969

CONS_SCORE: 0.7671

DSS_SCORE: 0.6461

HELIX: 0.1137

FCONS_SCORE: 1.2979

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P363H	TCGA-49-6761	LUAD	TCGA	PQTPLSE	DEG_SCF_FBW7_2	0.0556
p.R372L	TCGA-66-2783	LUSC	TCGA	PQTPLSE	DEG_SCF_FBW7_2	0.3056
p.L365M	TCGA-G2-A2EJ	BLCA	TCGA	PQTPLSE	DEG_SCF_FBW7_2	0.1111
p.A369T	TCGA-HU-A4GF	STAD	TCGA	PQTPLSE	DEG_SCF_FBW7_2	0.2222
p.P373L	SIDM00247	Gastric Carcinoma	GDSC	PQTPLSE	DEG_SCF_FBW7_2	0.6471
p.P373L	ACH-000356	Gastric Cancer	CCLE	PQTPLSE	DEG_SCF_FBW7_2	0.6471
p.P373L	MKN45	stomach	COSMIC	PQTPLSE	DEG_SCF_FBW7_2	0.6471
p.A369V	ACH-001518	Endometrial/Uterine Cancer	CCLE	PQTPLSE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SCF_FBW7_2	373:379	PQTPLSE	FBXW7	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons