DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_COP1_1

Location: 2771:2780

E3 ligase: COP1

DEGRON score: 0.8462

ASA_SCORE: 80.51

COIL: 0.7895

CONS_SCORE: 0.4935

DSS_SCORE: 0.6185

HELIX: 0.1215

FCONS_SCORE: 0.8151

RIG_SCORE: 0.6187

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2770S	TCGA-EE-A2MR	SKCM	TCGA	TQDSSAVPSA	DEG_COP1_1	0.3056
p.G2770S	DO37819	SKCM	ICGC	TQDSSAVPSA	DEG_COP1_1	0.3056
p.G2770D	TCGA-EE-A2MR	SKCM	TCGA	TQDSSAVPSA	DEG_COP1_1	0.3056
p.G2770D	DO37819	SKCM	ICGC	TQDSSAVPSA	DEG_COP1_1	0.3056
p.V2787I	DO227987	COCA	ICGC	TQDSSAVPSA	DEG_COP1_1	0.1389
p.R2790G	DO229013	COCA	ICGC	TQDSSAVPSA	DEG_COP1_1	0.0556
p.R2790G	DO229480	LAML	ICGC	TQDSSAVPSA	DEG_COP1_1	0.0556
p.R2790G	DO229505	LAML	ICGC	TQDSSAVPSA	DEG_COP1_1	0.0556
p.R2790G	DO230550	LUSC	ICGC	TQDSSAVPSA	DEG_COP1_1	0.0556
p.R2790G	DO231022	LUSC	ICGC	TQDSSAVPSA	DEG_COP1_1	0.0556
p.R2790G	DO231102	LUSC	ICGC	TQDSSAVPSA	DEG_COP1_1	0.0556
p.V2766F	DO229037	LICA	ICGC	TQDSSAVPSA	DEG_COP1_1	0.1944
p.Q2772E	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	TQDSSAVPSA	DEG_COP1_1	0.5633

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_COP1_1	2771:2780	TQDSSAVPSA	COP1	0.8462	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons