DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_APCC_DBOX_1

Location: 1946:1954

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9846

ASA_SCORE: 76.7778

COIL: 0.781

CONS_SCORE: 0.8483

DSS_SCORE: 0.6916

HELIX: 0.1016

FCONS_SCORE: 1.2259

RIG_SCORE: 0.6741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1947G	TCGA-17-Z031	LUAD	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	0.7568
p.A1959V	TCGA-AP-A1DV	UCEC	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	0.1944
p.A1959V	DO43186	UCEC	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	0.1944
p.E1956D	TCGA-BQ-7053	KIRP	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	0.2778
p.E1956D	DO20946	KIRP	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	0.2778
p.R1937S	TCGA-D9-A148	SKCM	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	0.0833
p.R1937S	DO37971	SKCM	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	0.0833
p.P1936L	TCGA-DT-5265	READ	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	0.0556
p.P1936L	DO36499	READ	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	0.0556
p.R1937H	TCGA-EY-A1GI	UCEC	TCGA	SRVSLTDIP	DEG_APCC_DBOX_1	0.0833
p.R1937H	DO41211	UCEC	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	0.0833
p.R1937H	SIDM00238	Ovarian Carcinoma	GDSC	SRVSLTDIP	DEG_APCC_DBOX_1	0.0833
p.R1937H	ACH-000947	Ovarian Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	0.0833
p.R1937H	OVK-18	ovary	COSMIC	SRVSLTDIP	DEG_APCC_DBOX_1	0.0833
p.P1936R	DO225319	BRCA	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	0.0556
p.T1962S	DO222755	COCA	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	0.1111
p.G1961E	DO220898	MELA	ICGC	SRVSLTDIP	DEG_APCC_DBOX_1	0.1389
p.T1955N	SIDM00789	Colorectal Carcinoma	GDSC	SRVSLTDIP	DEG_APCC_DBOX_1	0.3056
p.T1955N	ACH-000997	Colon/Colorectal Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	0.3056
p.T1955N	ACH-001061	Colon/Colorectal Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	0.3056
p.T1955N	ACH-001091	Colon/Colorectal Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	0.3056
p.T1955N	HCT-15	large_intestine	COSMIC	SRVSLTDIP	DEG_APCC_DBOX_1	0.3056
p.D1957E	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	SRVSLTDIP	DEG_APCC_DBOX_1	0.25
p.D1957E	ACH-001233	Lung Cancer	CCLE	SRVSLTDIP	DEG_APCC_DBOX_1	0.25
p.D1957E	VMRC-LCD	lung	COSMIC	SRVSLTDIP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_APCC_DBOX_1	1946:1954	SRVSLTDIP	APC,CDC20,FZR1	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRVSLTDIP

Degron related mutations and impact score

Drug responses associated with SPEG mutations

All proteins holding degron of SRVSLTDIP