DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_SCF_FBW7_1

Location: 170:176

E3 ligase: FBXW7

DEGRON score: 0.906

ASA_SCORE: 67.3

COIL: 0.5146

CONS_SCORE: 0.4925

DSS_SCORE: 0.6515

HELIX: 0.016

FCONS_SCORE: 1.0233

RIG_SCORE: 0.6974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S176F	TCGA-D3-A5GN	SKCM	TCGA	LDTPPTS	DEG_SCF_FBW7_1	0.7982
p.E182K	TCGA-RD-A7C1	STAD	TCGA	LDTPPTS	DEG_SCF_FBW7_1	0.1667
p.S165C	DO602	BLCA	ICGC	LDTPPTS	DEG_SCF_FBW7_1	0.1944
p.E170Q	DO14862	HNSC	ICGC	LDTPPTS	DEG_SCF_FBW7_1	0.6744
p.L186V	DO35254	PACA	ICGC	LDTPPTS	DEG_SCF_FBW7_1	0.0556
p.H167Y	DO229453	SKCA	ICGC	LDTPPTS	DEG_SCF_FBW7_1	0.25
p.R162W	DO43041	UCEC	ICGC	LDTPPTS	DEG_SCF_FBW7_1	0.1111
p.V177M	SIDM00210	Ovarian Carcinoma	GDSC	LDTPPTS	DEG_SCF_FBW7_1	0.3056
p.V177M	ACH-000657	Ovarian Cancer	CCLE	LDTPPTS	DEG_SCF_FBW7_1	0.3056
p.V177M	A2780	ovary	COSMIC	LDTPPTS	DEG_SCF_FBW7_1	0.3056
p.D184E	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	LDTPPTS	DEG_SCF_FBW7_1	0.1111
p.D184E	NCI-H2110	lung	COSMIC	LDTPPTS	DEG_SCF_FBW7_1	0.1111
p.L175S	NCI-H1793	lung	COSMIC	LDTPPTS	DEG_SCF_FBW7_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SCF_FBW7_1	170:176	LDTPPTS	FBXW7	0.906	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons