DegronMD

Uniprot ID: Q15772

Source protein: Striated muscle preferentially expressed protein kinase

Source gene: SPEG

Class: DEG_SCF_FBW7_2

Location: 642:649

E3 ligase: FBXW7

DEGRON score: 0.7277

ASA_SCORE: 85.4125

COIL: 0.7161

CONS_SCORE: 0.4709

DSS_SCORE: 0.5605

HELIX: 0.0251

FCONS_SCORE: 0.806

RIG_SCORE: 0.7018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R639C	TCGA-A6-2686	COAD	TCGA	PWATPGLE	DEG_SCF_FBW7_2	0.25
p.G655V	DO228971	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.1667
p.W651C	DO229019	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.2778
p.A643S	DO229022	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.7588
p.A633S	DO229027	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.0833
p.D654Y	DO229045	LICA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.1944
p.P645T	DO37643	SKCM	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.7031
p.G632E	DO48665	SKCM	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.0556
p.N644Y	DO229213	THCA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.7059
p.P646Q	DO39552	THCA	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.7035
p.R659H	DO43186	UCEC	ICGC	PWATPGLE	DEG_SCF_FBW7_2	0.1667
p.W643C	SIDM01156	Small Cell Lung Carcinoma	GDSC	PWATPGLE	DEG_SCF_FBW7_2	0.5889
p.W643C	ACH-000890	Lung Cancer	CCLE	PWATPGLE	DEG_SCF_FBW7_2	0.5889
p.A651S	ACH-000878	Lung Cancer	CCLE	PWATPGLE	DEG_SCF_FBW7_2	0.2778
p.T645M	ACH-001518	Endometrial/Uterine Cancer	CCLE	PWATPGLE	DEG_SCF_FBW7_2	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SCF_FBW7_2	642:649	PWATPGLE	FBXW7	0.7277	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons